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    RnrS Ribonucleoside diphosphate reductase small subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36280, updated on 17-Dec-2024

    Summary

    Official Symbol
    RnrSprovided by FlyBase
    Official Full Name
    Ribonucleoside diphosphate reductase small subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011704
    Locus tag
    Dmel_CG8975
    See related
    AllianceGenome:FB:FBgn0011704
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.148; CG8975; Dmel\CG8975; DmRNR2; dRNR2; R2; RNR-S; rnr2; Rnr2; RNR2; rnrS; Rnrs; RnRs; RNrS; RNRS
    Summary
    Enables cysteine-type endopeptidase activator activity involved in apoptotic process. Predicted to be involved in deoxyribonucleotide biosynthetic process. Predicted to be part of ribonucleoside-diphosphate reductase complex. Predicted to be active in cytosol. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; gut section; head epidermis primordium; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5; mitochondrial DNA depletion syndrome 8a; mitochondrial DNA depletion syndrome 8b; and pancreatic cancer. Orthologous to several human genes including RRM2 (ribonucleotide reductase regulatory subunit M2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See RnrS in Genome Data Viewer
    Location:
    48D5-48D5; 2-65 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11983145..11985393, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7870650..7872898, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene beta1,3-galactosyltransferase 1 Neighboring gene uncharacterized protein Neighboring gene rhomboid-7 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in deoxyribonucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in deoxyribonucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ribonucleoside-diphosphate reductase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    ribonucleoside diphosphate reductase small subunit
    Names
    CG8975-PA
    RnrS-PA
    ribonucleoside-diphosphate reductase small subunit
    ribonucleotide reductase
    ribonucleotide reductase small subunit
    NP_525111.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11983145..11985393 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080372.4NP_525111.1  ribonucleoside diphosphate reductase small subunit [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525111.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48592, Q9V640
      Related
      FBpp0087152
      Conserved Domains (1) summary
      cl00264
      Location:74393
      Ferritin_like; Ferritin-like superfamily of diiron-containing four-helix-bundle proteins