FAM21 Family with sequence similarity 21 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: FAM21provided by FlyBase
Official Full Name: Family with sequence similarity 21provided by FlyBase
Primary source: FLYBASE:FBgn0034529
Locus tag: Dmel_CG16742
See related: AllianceGenome:FB:FBgn0034529
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG16742; Dmel\CG16742; fam21; Fam21
Summary: Predicted to enable phosphatidylinositol phosphate binding activity and retromer complex binding activity. Involved in nuclear envelope budding and positive regulation of cell adhesion. Located in nucleoplasm. Part of WASH complex. Colocalizes with nuclear envelope. Orthologous to several human genes including WASHC2C (WASH complex subunit 2C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (20623547..20628315)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (16511052..16515820)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables phosphatidylinositol phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables retromer complex binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in nuclear envelope budding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to endosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde transport, endosome to Golgi	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of WASH complex	IBA Inferred from Biological aspect of Ancestor more info
part_of WASH complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain