U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    TPR3 TOPLESS-related 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832761, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    TPR3
    Official Full Name
    TOPLESS-related 3
    Primary source
    TAIR:AT5G27030
    Locus tag
    AT5G27030
    See related
    Araport:AT5G27030
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F2P16.14; F2P16_14; TOPLESS-related 3
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See TPR3 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    25
    Sequence:
    Chromosome: 5; NC_003076.8 (9508718..9515565, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ARM repeat superfamily protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene miscRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. AtMYB44 interacts with TOPLESS-RELATED corepressors to suppress protein phosphatase 2C gene transcription. Nguyen NH, et al. Biochem Biophys Res Commun, 2018 Dec 9. PMID 30448055
    2. TOPLESS mediates brassinosteroid-induced transcriptional repression through interaction with BZR1. Oh E, et al. Nat Commun, 2014 Jun 18. PMID 24938363, Free PMC Article
    3. TOPLESS regulates apical embryonic fate in Arabidopsis. Long JA, et al. Science, 2006 Jun 9. PMID 16763149
    4. The molecular mechanism of sporocyteless/nozzle in controlling Arabidopsis ovule development. Wei B, et al. Cell Res, 2015 Jan. PMID 25378179, Free PMC Article
    5. The Arabidopsis bHLH transcription factors MYC3 and MYC4 are targets of JAZ repressors and act additively with MYC2 in the activation of jasmonate responses. Fernández-Calvo P, et al. Plant Cell, 2011 Feb. PMID 21335373, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtMYB44 forms a complex with TPR corepressors and recruits histone deacetylase(s) to suppress PP2C gene transcription in a signal-independent manner.
      Title: AtMYB44 interacts with TOPLESS-RELATED corepressors to suppress protein phosphatase 2C gene transcription.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    NM_001203480.1
    NM_122585.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within primary shoot apical meristem specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    TOPLESS-related 3
    NP_001190409.1
    • TOPLESS-related 3 (TPR3); FUNCTIONS IN: protein binding; INVOLVED IN: primary shoot apical meristem specification; LOCATED IN: endomembrane system; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), CTLH, C-terminal LisH motif (InterPro:IPR006595), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), LisH dimerisation motif (InterPro:IPR006594), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: TOPLESS-related 2 (TAIR:AT3G16830.1).
    NP_198055.3
    • TOPLESS-related 3 (TPR3); FUNCTIONS IN: protein binding; INVOLVED IN: primary shoot apical meristem specification; LOCATED IN: endomembrane system; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), CTLH, C-terminal LisH motif (InterPro:IPR006595), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), LisH dimerisation motif (InterPro:IPR006594), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: TOPLESS-related 2 (TAIR:AT3G16830.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      9508718..9515565 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122585.5 → NP_198055.3  TOPLESS-related 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_198055.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q84JM4, Q9S9U5
      UniProtKB/TrEMBL
      A0A178UJX4, A0A5S9Y7H9, A0A654G4S4
      Conserved Domains (4) summary
      smart00667
      Location:4 → 34
      LisH; Lissencephaly type-1-like homology motif
      smart00668
      Location:34 → 92
      CTLH; C-terminal to LisH motif
      sd00039
      Location:410 → 450
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:337 → 656
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001203480.1 → NP_001190409.1  TOPLESS-related 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190409.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UJX4, A0A654G4S4, F4K2T3
      Conserved Domains (5) summary
      smart00667
      Location:4 → 34
      LisH; Lissencephaly type-1-like homology motif
      smart00668
      Location:34 → 92
      CTLH; C-terminal to LisH motif
      COG2319
      Location:466 → 969
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:410 → 476
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:337 → 682
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q84JM4.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools