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    LSP1 Eukaryotic initiation factor 4E protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 833534, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LSP1
    Official Full Name
    Eukaryotic initiation factor 4E protein
    Primary source
    TAIR:AT5G35620
    Locus tag
    AT5G35620
    See related
    Araport:AT5G35620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    EIF(ISO)4E; EIF4E2; eIFiso4E; EUKARYOTIC INITIATION FACTOR (ISO)4E; EUKARYOTIC INITIATION FACTOR (ISO)4E; EUKARYOTIC TRANSLATION INITATION FACTOR 4E2; eukaryotic translation Initiation Factor isoform 4E; LOSS OF SUSCEPTIBILITY TO POTYVIRUS 1; LSP; MJE4.8; MJE4_8
    Summary
    Cap-binding protein, binds to the 5' cap structure of nuclear-encoded mRNAs. Mutant is resistant to potyvirus infection.
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    Genomic context

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    See LSP1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (13824424..13826444, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Paired amphipathic helix (PAH2) superfamily protein Neighboring gene miscRNA Neighboring gene glutamine synthetase 2 Neighboring gene Putative endonuclease or glycosyl hydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Turnip mosaic virus VPg interacts with Arabidopsis thaliana eIF(iso)4E and inhibits in vitro translation. Miyoshi H, et al. Biochimie, 2008 Oct. PMID 18582528
    2. Loss-of-susceptibility mutants of Arabidopsis thaliana reveal an essential role for eIF(iso)4E during potyvirus infection. Lellis AD, et al. Curr Biol, 2002 Jun 25. PMID 12123581
    3. Selective involvement of members of the eukaryotic initiation factor 4E family in the infection of Arabidopsis thaliana by potyviruses. Sato M, et al. FEBS Lett, 2005 Feb 14. PMID 15710407
    4. Interaction of the viral protein genome linked of turnip mosaic potyvirus with the translational eukaryotic initiation factor (iso) 4E of Arabidopsis thaliana using the yeast two-hybrid system. Wittmann S, et al. Virology, 1997 Jul 21. PMID 9234949
    5. eIFiso4G Augments the Synthesis of Specific Plant Proteins Involved in Normal Chloroplast Function. Lellis AD, et al. Plant Physiol, 2019 Sep. PMID 31308150, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. eIFiso4G Augments the Synthesis of Specific Plant Proteins Involved in Normal Chloroplast Function.
      Title: eIFiso4G Augments the Synthesis of Specific Plant Proteins Involved in Normal Chloroplast Function.
    2. Turnip mosaic virus protein linked to the genome (VPg) inhibits cap-dependent translational initiation via binding to eIF(iso)4E. [eIF(iso)4E]
      Title: Turnip mosaic virus VPg interacts with Arabidopsis thaliana eIF(iso)4E and inhibits in vitro translation.
    3. Turnip mosaic virus (TuMV), another member of the genus Potyvirus, multiplied in mutant plants lacking eIF4E but not in mutant
      Title: Selective involvement of members of the eukaryotic initiation factor 4E family in the infection of Arabidopsis thaliana by potyviruses.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_122953.3
    NM_203123.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA 7-methylguanosine cap binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation initiation factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within translational initiation TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    Eukaryotic initiation factor 4E protein
    NP_198412.1
    • LOSS OF SUSCEPTIBILITY TO POTYVIRUS 1 (LSP1); FUNCTIONS IN: RNA binding, RNA 7-methylguanosine cap binding, translation initiation factor activity; INVOLVED IN: translational initiation, response to virus; LOCATED IN: nucleus, cytoplasm; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Eukaryotic translation initiation factor 4E (eIF-4E) (InterPro:IPR001040), Eukaryotic translation initiation factor 4E (eIF-4E), conserved site (InterPro:IPR019770); BEST Arabidopsis thaliana protein match is: eukaryotic translation initiation factor 4E (TAIR:AT4G18040.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
    NP_974852.1
    • LOSS OF SUSCEPTIBILITY TO POTYVIRUS 1 (LSP1); FUNCTIONS IN: RNA binding, RNA 7-methylguanosine cap binding, translation initiation factor activity; INVOLVED IN: translational initiation, response to virus; LOCATED IN: nucleus, cytoplasm; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Eukaryotic translation initiation factor 4E (eIF-4E) (InterPro:IPR001040), Eukaryotic translation initiation factor 4E (eIF-4E), conserved site (InterPro:IPR019770); BEST Arabidopsis thaliana protein match is: eukaryotic translation initiation factor 4E (TAIR:AT4G18040.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      13824424..13826444 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001344112.1 → NP_001332369.1  Eukaryotic initiation factor 4E protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04663, Q3E8N6, Q546X5, Q9SAN8
      UniProtKB/TrEMBL
      A0A178UEE3, A0A5S9Y8A9
      Conserved Domains (1) summary
      pfam01652
      Location:27 → 185
      IF4E; Eukaryotic initiation factor 4E

    2. NM_122953.3 → NP_198412.1  Eukaryotic initiation factor 4E protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_198412.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04663, Q3E8N6, Q546X5, Q9SAN8
      UniProtKB/TrEMBL
      A0A178UEE3, A0A5S9Y8A9
      Conserved Domains (1) summary
      pfam01652
      Location:27 → 185
      IF4E; Eukaryotic initiation factor 4E

    3. NM_203123.1 → NP_974852.1  Eukaryotic initiation factor 4E protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974852.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04663
      Conserved Domains (1) summary
      pfam01652
      Location:31 → 166
      IF4E; Eukaryotic initiation factor 4E
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O04663.2

    Gene LinkOut

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