U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    DNA polymerase delta subunit 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836517, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Full Name
    DNA polymerase delta subunit 1
    Primary source
    TAIR:AT5G63960
    Locus tag
    AT5G63960
    See related
    Araport:AT5G63960
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    EMBRYO DEFECTIVE 2780; MBM17.6; MBM17_6
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: 5
    Exon count:
    30
    Sequence:
    Chromosome: 5; NC_003076.8 (25599514..25606841)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene chromatin remodeling 24 Neighboring gene Copine (Calcium-dependent phospholipid-binding protein) family Neighboring gene SAL1 phosphatase-like protein Neighboring gene Inositol monophosphatase family protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The Largest Subunit of DNA Polymerase Delta Is Required for Normal Formation of Meiotic Type I Crossovers. Wang C, et al. Plant Physiol, 2019 Feb. PMID 30459265, Free PMC Article
    2. The arabidopsis DNA polymerase δ has a role in the deposition of transcriptionally active epigenetic marks, development and flowering. Iglesias FM, et al. PLoS Genet, 2015 Feb. PMID 25693187, Free PMC Article
    3. Replication stress leads to genome instabilities in Arabidopsis DNA polymerase delta mutants. Schuermann D, et al. Plant Cell, 2009 Sep. PMID 19789281, Free PMC Article
    4. CDKB1;1 forms a functional complex with CYCA2;3 to suppress endocycle onset. Boudolf V, et al. Plant Physiol, 2009 Jul. PMID 19458112, Free PMC Article
    5. Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana. Van Leene J, et al. Mol Syst Biol, 2010 Aug 10. PMID 20706207, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. POLD1(At5g63960) is important for the formation of type I meiotic crossovers.POLD1 is important for synapsis.
      Title: The Largest Subunit of DNA Polymerase Delta Is Required for Normal Formation of Meiotic Type I Crossovers.
    2. These results strongly suggest that the DNA polymerase delta is required for the proper establishment of transcriptionally active epigenetic marks and that its failure might affect development by affecting the epigenetic control of master genes.
      Title: The arabidopsis DNA polymerase δ has a role in the deposition of transcriptionally active epigenetic marks, development and flowering.
    3. Arabidopsis plants mutated in the POL1 gene show enhanced frequencies of somatic intramolecular homologous recombination.
      Title: Replication stress leads to genome instabilities in Arabidopsis DNA polymerase delta mutants.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_001203682.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    DNA polymerase delta subunit 1
    NP_001190611.1
    • FUNCTIONS IN: DNA-directed DNA polymerase activity, DNA binding, nucleotide binding, nucleic acid binding; INVOLVED IN: DNA replication, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; CONTAINS InterPro DOMAIN/s: DNA polymerase, family B (InterPro:IPR022762), DNA-directed DNA polymerase, family B, exonuclease domain (InterPro:IPR006133), DNA-directed DNA polymerase, family B, conserved region (InterPro:IPR006134), Polynucleotidyl transferase, ribonuclease H fold (InterPro:IPR012337), DNA-directed DNA polymerase, family B, conserved site (InterPro:IPR017964), DNA-directed DNA polymerase, family B (InterPro:IPR006172), DNA-directed DNA polymerase, family B, pol2 (InterPro:IPR004578); BEST Arabidopsis thaliana protein match is: recovery protein 3 (TAIR:AT1G67500.2).
    NP_201201.2
    • FUNCTIONS IN: DNA-directed DNA polymerase activity, DNA binding, nucleotide binding, nucleic acid binding; INVOLVED IN: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, DNA replication; CONTAINS InterPro DOMAIN/s: DNA polymerase, family B (InterPro:IPR022762), DNA-directed DNA polymerase, family B, exonuclease domain (InterPro:IPR006133), DNA-directed DNA polymerase, family B, conserved region (InterPro:IPR006134), Polynucleotidyl transferase, ribonuclease H fold (InterPro:IPR012337), DNA-directed DNA polymerase, family B, conserved site (InterPro:IPR017964), DNA-directed DNA polymerase, family B (InterPro:IPR006172), DNA-directed DNA polymerase, family B, pol2 (InterPro:IPR004578); BEST Arabidopsis thaliana protein match is: recovery protein 3 (TAIR:AT1G67500.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      25599514..25606841
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125792.2 → NP_201201.2  DNA polymerase delta subunit 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201201.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0MA44, Q9LVN7
      UniProtKB/TrEMBL
      A0A178UA08, A0A5S9YHB3
      Conserved Domains (1) summary
      PTZ00166
      Location:81 → 1092
      PTZ00166; DNA polymerase delta catalytic subunit; Provisional

    2. NM_001203682.1 → NP_001190611.1  DNA polymerase delta subunit 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190611.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9YHB3, F4KC69
      Conserved Domains (4) summary
      cd05777
      Location:300 → 546
      DNA_polB_delta_exo; DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase delta, a family-B DNA polymerase
      cd05533
      Location:595 → 988
      POLBc_delta; DNA polymerase type-B delta subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. Presently, no direct data is available regarding ...
      PTZ00166
      Location:81 → 1109
      PTZ00166; DNA polymerase delta catalytic subunit; Provisional
      pfam14260
      Location:1024 → 1093
      zf-C4pol; C4-type zinc-finger of DNA polymerase delta
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LVN7.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools