U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    NIK1 NSP-interacting kinase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831457, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    NIK1
    Official Full Name
    NSP-interacting kinase 1
    Primary source
    TAIR:AT5G16000
    Locus tag
    AT5G16000
    See related
    Araport:AT5G16000
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtNIK1; F1N13.140; F1N13_140; NSP-interacting kinase 1
    Summary
    NSP-interacting kinase (NIK1), receptor-like kinase, involved in defense response against geminivirus It acts as a virulence target of the begomovirus nuclear shuttle protein (NSP).
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See NIK1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    9
    Sequence:
    Chromosome: 5; NC_003076.8 (5223934..5227288)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene 3-oxo-5-alpha-steroid 4-dehydrogenase family protein Neighboring gene gamete-expressed 3

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. NIK1, a host factor specialized in antiviral defense or a novel general regulator of plant immunity? Machado JP, et al. Bioessays, 2015 Nov. PMID 26335701
    2. Conserved threonine residues within the A-loop of the receptor NIK differentially regulate the kinase function required for antiviral signaling. Santos AA, et al. PLoS One, 2009 Jun 3. PMID 19492062, Free PMC Article
    3. The receptor-like kinase NIK1 targets FLS2/BAK1 immune complex and inversely modulates antiviral and antibacterial immunity. Li B, et al. Nat Commun, 2019 Nov 1. PMID 31676803, Free PMC Article
    4. NIK1-mediated translation suppression functions as a plant antiviral immunity mechanism. Zorzatto C, et al. Nature, 2015 Apr 30. PMID 25707794, Free PMC Article
    5. Regulated nuclear trafficking of rpL10A mediated by NIK1 represents a defense strategy of plant cells against virus. Carvalho CM, et al. PLoS Pathog, 2008 Dec. PMID 19112492, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NSP-interacting kinase 1 (NIK1) negatively regulates the formation of FLAGELLIN-SENSITIVE 2 protein (FLS2) / SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE 3 (BAK1) complex.
      Title: The receptor-like kinase NIK1 targets FLS2/BAK1 immune complex and inversely modulates antiviral and antibacterial immunity.
    2. NIK1 activation mediates the translocation of RPL10 to the nucleus, where it interacts with LIMYB to fully down-regulate translational machinery genes, resulting in translation inhibition of host and viral mRNAs and enhanced tolerance to begomovirus.
      Title: NIK1, a host factor specialized in antiviral defense or a novel general regulator of plant immunity?
    3. the constitutive activation of NIK1, a virulence target of the begomovirus nuclear shuttle protein (NSP), leads to global translation suppression and translocation of the downstream component RPL10 to the nucleus
      Title: NIK1-mediated translation suppression functions as a plant antiviral immunity mechanism.
    4. Geminivirus infection directly interferes with NIK1-mediated nuclear relocalization of rpL10A as a counterdefensive measure.
      Title: Regulated nuclear trafficking of rpL10A mediated by NIK1 represents a defense strategy of plant cells against virus.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_121605.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    NSP-interacting kinase 1
    NP_197104.1
    • NSP-interacting kinase 1 (NIK1); FUNCTIONS IN: kinase activity; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: NSP-interacting kinase 2 (TAIR:AT3G25560.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      5223934..5227288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121605.3 → NP_197104.1  NSP-interacting kinase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197104.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LA44, Q9LFS4
      UniProtKB/TrEMBL
      A0A178UEW6, A0A5S9Y580
      Conserved Domains (5) summary
      smart00219
      Location:318 → 583
      TyrKc; Tyrosine kinase, catalytic domain
      sd00033
      Location:107 → 130
      LRR_RI; leucine-rich repeat [structural motif]
      pfam08263
      Location:39 → 78
      LRRNT_2; Leucine rich repeat N-terminal domain
      pfam13855
      Location:129 → 189
      LRR_8; Leucine rich repeat
      cl21453
      Location:318 → 586
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LFS4.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools