U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    PLA2A phospholipase A 2A [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817197, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    PLA2A
    Official Full Name
    phospholipase A 2A
    Primary source
    TAIR:AT2G26560
    Locus tag
    AT2G26560
    See related
    Araport:AT2G26560
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    PATATIN-LIKE PROTEIN 2; phospholipase A 2A; PHOSPHOLIPASE A 2A; PLA IIA; PLAII alpha; PLP2; T9J22.23; T9J22_23
    Summary
    Encodes a lipid acyl hydrolase with wide substrate specificity that accumulates upon infection by fungal and bacterial pathogens. Protein is localized in the cytoplasm in healthy leaves, and in membranes in infected cells. Plays a role in cell death and differentially affects the accumulation of oxylipins. Contributes to resistance to virus.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PLA2A in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    6
    Sequence:
    Chromosome: 2; NC_003071.7 (11293702..11295918, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene uroporphyrinogen-III synthase family protein Neighboring gene heme oxygenase 2 Neighboring gene WEAK CHLOROPLAST MOVEMENT UNDER BLUE LIGHT-like protein (DUF827) Neighboring gene plant-specific transcription factor YABBY family protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The Arabidopsis patatin-like protein 2 (PLP2) plays an essential role in cell death execution and differentially affects biosynthesis of oxylipins and resistance to pathogens. La Camera S, et al. Mol Plant Microbe Interact, 2009 Apr. PMID 19271961
    2. A pathogen-inducible patatin-like lipid acyl hydrolase facilitates fungal and bacterial host colonization in Arabidopsis. La Camera S, et al. Plant J, 2005 Dec. PMID 16297072
    3. Proteome changes in Arabidopsis thaliana roots upon exposure to Cd2+. Roth U, et al. J Exp Bot, 2006. PMID 17075075
    4. The AP2/ERF transcription factor AtERF73/HRE1 modulates ethylene responses during hypoxia in Arabidopsis. Yang CY, et al. Plant Physiol, 2011 May. PMID 21398256, Free PMC Article
    5. Extensive signal integration by the phytohormone protein network. Altmann M, et al. Nature, 2020 Jul. PMID 32612234

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PLP2 contributes to resistance to Cucumber mosaic virus, plays an essential role in cell death, and differentially affects biosynthesis of oxylipins and resistance to pathogens.
      Title: The Arabidopsis patatin-like protein 2 (PLP2) plays an essential role in cell death execution and differentially affects biosynthesis of oxylipins and resistance to pathogens.
    2. PLP2 is a pathogen-inducible patatin-like lipid acyl hydrolase that can be exploited by pathogens to facilitate host colonization.[PLP2]
      Title: A pathogen-inducible patatin-like lipid acyl hydrolase facilitates fungal and bacterial host colonization in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    NM_128213.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables lipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within oxylipin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within plant-type hypersensitive response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within plant-type hypersensitive response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cadmium ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    phospholipase A 2A
    NP_180224.1
    • phospholipase A 2A (PLA2A); FUNCTIONS IN: lipase activity, nutrient reservoir activity; INVOLVED IN: in 6 processes; LOCATED IN: membrane, cytoplasm; EXPRESSED IN: 11 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Acyl transferase/acyl hydrolase/lysophospholipase (InterPro:IPR016035), Patatin (InterPro:IPR002641); BEST Arabidopsis thaliana protein match is: Acyl transferase/acyl hydrolase/lysophospholipase superfamily protein (TAIR:AT4G37070.2); Has 2114 Blast hits to 2104 proteins in 375 species: Archae - 0; Bacteria - 479; Metazoa - 231; Fungi - 198; Plants - 897; Viruses - 0; Other Eukaryotes - 309 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      11293702..11295918 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128213.4 → NP_180224.1  phospholipase A 2A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180224.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O48723, Q8LDK8
      UniProtKB/TrEMBL
      A0A178VSV3, A0A5S9X1E3
      Conserved Domains (1) summary
      cd07214
      Location:16 → 366
      Pat17_isozyme_like; Patatin-like phospholipase of plants
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O48723.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools