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    DRH1 DEAD box RNA helicase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821116, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DRH1
    Official Full Name
    DEAD box RNA helicase 1
    Primary source
    TAIR:AT3G01540
    Locus tag
    AT3G01540
    See related
    Araport:AT3G01540
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA DEAD BOX RNA HELICASE 1; ATDRH1; DEAD box RNA helicase 1; F4P13.9; F4P13_9; RNA HELICASE DRH1
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    Genomic context

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    See DRH1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    10
    Sequence:
    Chromosome: 3; NC_003074.8 (212518..216736, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Adenine nucleotide alpha hydrolases-like superfamily protein Neighboring gene myb domain protein 57 Neighboring gene phosphoenolpyruvate (pep)/phosphate translocator 2 Neighboring gene proline-rich receptor-like kinase, putative (DUF1421) Neighboring gene Oleosin family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of a DEAD box ATPase/RNA helicase protein of Arabidopsis thaliana. Okanami M, et al. Nucleic Acids Res, 1998 Jun 1. PMID 9592148, Free PMC Article
    2. Nucleocytoplasmic trafficking is essential for BAK1- and BKK1-mediated cell-death control. Du J, et al. Plant J, 2016 Feb. PMID 26775605
    3. Loss of INCREASED SIZE EXCLUSION LIMIT (ISE)1 or ISE2 increases the formation of secondary plasmodesmata. Burch-Smith TM, et al. Curr Biol, 2010 Jun 8. PMID 20434343, Free PMC Article
    4. Loss of the plant DEAD-box protein ISE1 leads to defective mitochondria and increased cell-to-cell transport via plasmodesmata. Stonebloom S, et al. Proc Natl Acad Sci U S A, 2009 Oct 6. PMID 19805190, Free PMC Article
    5. Plant-specific ribosome biogenesis factors in Arabidopsis thaliana with essential function in rRNA processing. Palm D, et al. Nucleic Acids Res, 2019 Feb 28. PMID 30576513, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A DEAD-box RNA helicase, DRH1, was identified in the same protein complex as SBB1 via a proteomic approach. The drh1 mutation also rescues the cell-death symptoms of bak1-3 bkk1-1.
      Title: Nucleocytoplasmic trafficking is essential for BAK1- and BKK1-mediated cell-death control.
    2. Data show that silencing of ISE1 and ISE2 phenocopies ise1 and ise2 mutant embryos: when wild-type ISE1 and ISE2 functions are lost, de novo production of plasmodesmata occurs, leading to increased intercellular transport.
      Title: Loss of INCREASED SIZE EXCLUSION LIMIT (ISE)1 or ISE2 increases the formation of secondary plasmodesmata.
    3. Data show that ISE1 encodes a putative plant-specific DEAD-box RNA helicase that localizes specifically to mitochondria.
      Title: Loss of the plant DEAD-box protein ISE1 leads to defective mitochondria and increased cell-to-cell transport via plasmodesmata.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001035542.1
    NM_111020.3
    NM_180161.2
    NM_202477.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    DEAD box RNA helicase 1
    NP_001030619.1
    • DEAD box RNA helicase 1 (DRH1); FUNCTIONS IN: ATPase activity, ATP-dependent RNA helicase activity; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: DNA/RNA helicase, DEAD/DEAH box type, N-terminal (InterPro:IPR011545), RNA helicase, ATP-dependent, DEAD-box, conserved site (InterPro:IPR000629), RNA helicase, DEAD-box type, Q motif (InterPro:IPR014014), WW/Rsp5/WWP (InterPro:IPR001202), DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021); BEST Arabidopsis thaliana protein match is: DEAD box RNA helicase family protein (TAIR:AT5G14610.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_566141.1
    • DEAD box RNA helicase 1 (DRH1); FUNCTIONS IN: ATPase activity, ATP-dependent RNA helicase activity; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: DNA/RNA helicase, DEAD/DEAH box type, N-terminal (InterPro:IPR011545), RNA helicase, ATP-dependent, DEAD-box, conserved site (InterPro:IPR000629), RNA helicase, DEAD-box type, Q motif (InterPro:IPR014014), WW/Rsp5/WWP (InterPro:IPR001202), DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021); BEST Arabidopsis thaliana protein match is: DEAD box RNA helicase family protein (TAIR:AT5G14610.2); Has 49839 Blast hits to 48969 proteins in 3110 species: Archae - 949; Bacteria - 26028; Metazoa - 6650; Fungi - 4984; Plants - 2792; Viruses - 23; Other Eukaryotes - 8413 (source: NCBI BLink).
    NP_850492.1
    • DEAD box RNA helicase 1 (DRH1); FUNCTIONS IN: ATPase activity, ATP-dependent RNA helicase activity; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: DNA/RNA helicase, DEAD/DEAH box type, N-terminal (InterPro:IPR011545), RNA helicase, ATP-dependent, DEAD-box, conserved site (InterPro:IPR000629), RNA helicase, DEAD-box type, Q motif (InterPro:IPR014014), WW/Rsp5/WWP (InterPro:IPR001202), DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021); BEST Arabidopsis thaliana protein match is: DEAD box RNA helicase family protein (TAIR:AT5G14610.2); Has 50187 Blast hits to 49315 proteins in 3135 species: Archae - 949; Bacteria - 26432; Metazoa - 6592; Fungi - 4988; Plants - 2789; Viruses - 23; Other Eukaryotes - 8414 (source: NCBI BLink).
    NP_974206.1
    • DEAD box RNA helicase 1 (DRH1); FUNCTIONS IN: ATPase activity, ATP-dependent RNA helicase activity; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: DNA/RNA helicase, DEAD/DEAH box type, N-terminal (InterPro:IPR011545), RNA helicase, ATP-dependent, DEAD-box, conserved site (InterPro:IPR000629), RNA helicase, DEAD-box type, Q motif (InterPro:IPR014014), WW/Rsp5/WWP (InterPro:IPR001202), DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021); BEST Arabidopsis thaliana protein match is: DEAD box RNA helicase family protein (TAIR:AT5G14610.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      212518..216736 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001035542.1 → NP_001030619.1  DEAD box RNA helicase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001030619.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64430, Q8H136, Q8W4F5, Q93WJ3
      UniProtKB/TrEMBL
      A0A5S9X899, A0A654F363
      Conserved Domains (2) summary
      PTZ00110
      Location:83 → 549
      PTZ00110; helicase; Provisional
      pfam00397
      Location:19 → 49
      WW; WW domain

    2. NM_180161.2 → NP_850492.1  DEAD box RNA helicase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850492.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64430, Q8H136, Q8W4F5, Q93WJ3
      UniProtKB/TrEMBL
      A0A5S9X899, A0A654F363
      Conserved Domains (2) summary
      PTZ00110
      Location:83 → 549
      PTZ00110; helicase; Provisional
      pfam00397
      Location:19 → 49
      WW; WW domain

    3. NM_111020.3 → NP_566141.1  DEAD box RNA helicase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566141.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9X899
      Conserved Domains (4) summary
      cd00079
      Location:377 → 505
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:160 → 364
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      PTZ00110
      Location:83 → 549
      PTZ00110; helicase; Provisional
      pfam00397
      Location:19 → 49
      WW; WW domain

    4. NM_202477.2 → NP_974206.1  DEAD box RNA helicase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974206.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64430, Q8H136, Q8W4F5, Q93WJ3
      UniProtKB/TrEMBL
      A0A5S9X899, A0A654F363
      Conserved Domains (2) summary
      PTZ00110
      Location:83 → 549
      PTZ00110; helicase; Provisional
      pfam00397
      Location:19 → 49
      WW; WW domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8H136.2

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