Recql5 RecQ like helicase 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Recql5provided by RGD
Official Full Name: RecQ like helicase 5provided by RGD
Primary source: RGD:1310823
See related: EnsemblRapid:ENSRNOG00000005107 AllianceGenome:RGD:1310823
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RecQ5
Summary: Predicted to enable DNA helicase activity; RNA polymerase II complex binding activity; and identical protein binding activity. Predicted to be involved in DNA metabolic process; chromosome separation; and negative regulation of transcription elongation by RNA polymerase II. Predicted to act upstream of or within several processes, including cellular response to camptothecin; negative regulation of double-strand break repair via homologous recombination; and replication-born double-strand break repair via sister chromatid exchange. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of transcription preinitiation complex. Predicted to be active in cytoplasm; nucleus; and replication fork. Orthologous to human RECQL5 (RecQ like helicase 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 69.3), Spleen (RPKM 62.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (101625477..101664582, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (101126544..101165739, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (104443735..104482889, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH142484 (e-PCR)
- UniSTS:231731

RH128394 (e-PCR)
- UniSTS:211702

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3'-5' DNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables DNA helicase activity	ISO Inferred from Sequence Orthology more info
enables DNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II complex binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II complex binding	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables double-stranded DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables forked DNA-dependent helicase activity	IEA Inferred from Electronic Annotation more info
enables four-way junction helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables helicase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables single-stranded 3'-5' DNA helicase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in DNA repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA replication	ISO Inferred from Sequence Orthology more info
involved_in DNA replication	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA unwinding involved in DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to camptothecin	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in chromosome separation	ISO Inferred from Sequence Orthology more info
involved_in chromosome separation	ISS Inferred from Sequence or Structural Similarity more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic DNA-templated DNA replication	ISO Inferred from Sequence Orthology more info
involved_in mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription elongation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription elongation by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within replication-born double-strand break repair via sister chromatid exchange	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in chromosome	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in replication fork	ISO Inferred from Sequence Orthology more info
part_of transcription preinitiation complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ATP-dependent DNA helicase Q5

Names: DNA 3'-5' helicase RecQ5; DNA helicase, RecQ-like type 5; RecQ helicase-like 5; RecQ protein-like 5

NP_001099323.1

EC 5.6.2.4

XP_017452650.1

EC 5.6.2.4

XP_038941602.1

EC 5.6.2.4

XP_038941603.1

EC 5.6.2.4

XP_038941604.1

EC 5.6.2.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105853.1 → NP_001099323.1 ATP-dependent DNA helicase Q5

See identical proteins and their annotated locations for NP_001099323.1

Status: PROVISIONAL

Source sequence(s)

CH473948

UniProtKB/Swiss-Prot

D4ACP5

UniProtKB/TrEMBL

A0A8I6ALQ3

Related

ENSRNOP00000007246.4, ENSRNOT00000007246.7

Conserved Domains (5) summary

smart00487
Location:22 → 229

DEXDc; DEAD-like helicases superfamily

cd00079
Location:258 → 363

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

pfam00270
Location:31 → 201

DEAD; DEAD/DEAH box helicase

pfam06959
Location:626 → 816

RecQ5; RecQ helicase protein-like 5 (RecQ5)

pfam16124
Location:368 → 435

RecQ_Zn_bind; RecQ zinc-binding

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

101625477..101664582 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085674.2 → XP_038941602.1 ATP-dependent DNA helicase Q5 isoform X1

UniProtKB/TrEMBL

A0A8I6ALQ3

Related

ENSRNOP00000107175.1, ENSRNOT00000143862.1

Conserved Domains (2) summary

COG0514
Location:15 → 439

RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]

pfam06959
Location:600 → 771

RecQ5; RecQ helicase protein-like 5 (RecQ5)
XM_017597161.3 → XP_017452650.1 ATP-dependent DNA helicase Q5 isoform X2

UniProtKB/TrEMBL

A0A8I6ALQ3

Related

ENSRNOP00000106280.1, ENSRNOT00000144127.1
XM_039085675.2 → XP_038941603.1 ATP-dependent DNA helicase Q5 isoform X3

Conserved Domains (2) summary

pfam06959
Location:223 → 413

RecQ5; RecQ helicase protein-like 5 (RecQ5)

pfam16124
Location:8 → 32

RecQ_Zn_bind; RecQ zinc-binding
XM_039085676.2 → XP_038941604.1 ATP-dependent DNA helicase Q5 isoform X4

Conserved Domains (1) summary

COG0514
Location:15 → 414

RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]