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    Adnp2 ADNP homeobox 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307236, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Adnp2provided by RGD
    Official Full Name
    ADNP homeobox 2provided by RGD
    Primary source
    RGD:1308279
    See related
    EnsemblRapid:ENSRNOG00000053370 AllianceGenome:RGD:1308279
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308279
    Summary
    Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be involved in nervous system development. Predicted to be located in nucleus. Orthologous to human ADNP2 (ADNP homeobox 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 68.2), Lung (RPKM 62.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adnp2 in Genome Data Viewer
    Location:
    18q12.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (75846860..75871638, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (73571870..73597088, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (76637415..76661186, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene SNW domain containing 1, pseudogene 5 Neighboring gene par-6 family cell polarity regulator gamma Neighboring gene uncharacterized LOC120098235 Neighboring gene uncharacterized LOC134483064 Neighboring gene uncharacterized LOC108348824 Neighboring gene 60S acidic ribosomal protein P0 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Silencing of the ADNP-family member, ADNP2, results in changes in cellular viability under oxidative stress. Kushnir M, et al. J Neurochem, 2008 Apr. PMID 18179478
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC188386

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nervous system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    activity-dependent neuroprotector homeobox protein 2
    Names
    ADNP homeobox protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127373.1 → NP_001120845.1  activity-dependent neuroprotector homeobox protein 2

      See identical proteins and their annotated locations for NP_001120845.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166606
      UniProtKB/TrEMBL
      A0A8I6A6N1, B2GVB8
      Related
      ENSRNOP00000076656.2, ENSRNOT00000106123.2
      Conserved Domains (2) summary
      smart00389
      Location:1045 → 1098
      HOX; Homeodomain
      pfam15757
      Location:347 → 479
      Amelotin; Amelotin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      75846860..75871638 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096772.2 → XP_038952700.1  activity-dependent neuroprotector homeobox protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZJ89, A0A8I6A6N1
      Related
      ENSRNOP00000094768.2, ENSRNOT00000096066.2
      Conserved Domains (2) summary
      smart00389
      Location:1103 → 1156
      HOX; Homeodomain
      PHA03247
      Location:334 → 797
      PHA03247; large tegument protein UL36; Provisional

    2. XM_063277295.1 → XP_063133365.1  activity-dependent neuroprotector homeobox protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AMU3
    Nucleotide Protein Strain
    Heading Accession and Version

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