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    Ipo8 importin 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 686774, updated on 27-Dec-2024

    Summary

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    Symbol
    Ipo8provided by RGD
    Full Name
    importin 8provided by RGD
    Primary source
    RGD:1593688
    See related
    EnsemblRapid:ENSRNOG00000056041 AllianceGenome:RGD:1593688
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    AABR07062570.1
    Summary
    Predicted to enable small GTPase binding activity. Predicted to be involved in protein import into nucleus. Predicted to be active in cytosol and nuclear envelope. Orthologous to human IPO8 (importin 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 79.7), Liver (RPKM 69.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ipo8 in Genome Data Viewer
    Location:
    4q44
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (183460583..183529259, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (181729216..181793672, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (183228688..183295253, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102440 Neighboring gene uncharacterized LOC102555276 Neighboring gene hes-related family bHLH transcription factor with YRPW motif-like, pseudogene 1 Neighboring gene RNA, U2 small nuclear 45 Neighboring gene 40S ribosomal protein S23 pseudogene Neighboring gene caprin family member 2 Neighboring gene phosphatidylinositol transfer protein, beta, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MAPK inhibitors modulate Smad2/3/4 complex cyto-nuclear translocation in myofibroblasts via Imp7/8 mediation. Jiang Y, et al. Mol Cell Biochem, 2015 Aug. PMID 25968067
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MAPK-specific inhibitors blocked nuclear translocation of Smad2/3/4 complex through inhibition of Imp7/8 protein expression.
      Title: MAPK inhibitors modulate Smad2/3/4 complex cyto-nuclear translocation in myofibroblasts via Imp7/8 mediation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    importin-8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001400882.1 → NP_001387811.1  importin-8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A0G2K6J6
      Related
      ENSRNOP00000073839.2, ENSRNOT00000079695.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      183460583..183529259 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286698.1 → XP_063142768.1  importin-8 isoform X1

    2. XM_039108919.2 → XP_038964847.1  importin-8 isoform X2

      Conserved Domains (1) summary
      COG5656
      Location:15 → 995
      SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein Strain
    Heading Accession and Version

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