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    Trub2 TruB pseudouridine synthase family member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366012, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Trub2provided by RGD
    Official Full Name
    TruB pseudouridine synthase family member 2provided by RGD
    Primary source
    RGD:1359394
    See related
    EnsemblRapid:ENSRNOG00000043189 AllianceGenome:RGD:1359394
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable pseudouridine synthase activity. Predicted to be involved in mRNA pseudouridine synthesis and positive regulation of mitochondrial translation. Predicted to be located in mitochondrial matrix and ribonucleoprotein granule. Orthologous to human TRUB2 (TruB pseudouridine synthase family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 205.9), Heart (RPKM 178.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Trub2 in Genome Data Viewer
    Location:
    3p12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (33447101..33457712, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (13049220..13059836, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (8338479..8348746, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene golgin A2 like 1 Neighboring gene uncharacterized LOC134486066 Neighboring gene coenzyme Q4 Neighboring gene solute carrier family 27 member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation. Arroyo JD, et al. Cell Metab, 2016 Dec 13. PMID 27667664, Free PMC Article
    2. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pseudouridine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pseudouridine synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pseudouridine synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables tRNA pseudouridine(55) synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA pseudouridine synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitochondrial translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitochondrial translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in pseudouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pseudouridylate synthase TRUB2, mitochondrial
    Names
    TruB pseudouridine (psi) synthase family member 2
    mitochondrial mRNA pseudouridine synthase Trub2
    probable tRNA pseudouridine synthase 2
    psi55 synthase TRUB2
    tRNA pseudouridine 55 synthase TRUB2
    truB pseudouridine synthase homolog 2
    NP_001014279.1
    XP_038961507.1
    XP_038961508.1
    XP_038961509.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014257.2 → NP_001014279.1  pseudouridylate synthase TRUB2, mitochondrial

      See identical proteins and their annotated locations for NP_001014279.1

      Status: VALIDATED

      Source sequence(s)
      BC084712, CB613146
      UniProtKB/Swiss-Prot
      Q5XFW2
      UniProtKB/TrEMBL
      A0A8L2UNE5, A6JTS1
      Related
      ENSRNOP00000063203.4, ENSRNOT00000064638.5
      Conserved Domains (1) summary
      cd02868
      Location:11 → 283
      PseudoU_synth_hTruB2_like; Pseudouridine synthase, humanTRUB2_like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      33447101..33457712 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105580.2 → XP_038961508.1  pseudouridylate synthase TRUB2, mitochondrial isoform X2

      Conserved Domains (1) summary
      cl00130
      Location:56 → 161
      PseudoU_synth; Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi)

    2. XM_039105581.2 → XP_038961509.1  pseudouridylate synthase TRUB2, mitochondrial isoform X3

      Conserved Domains (1) summary
      cl00130
      Location:22 → 128
      PseudoU_synth; Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi)

    3. XM_039105579.2 → XP_038961507.1  pseudouridylate synthase TRUB2, mitochondrial isoform X1

      Conserved Domains (1) summary
      cl00130
      Location:11 → 179
      PseudoU_synth; Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XFW2.1 GenPept UniProtKB/Swiss-Prot:Q5XFW2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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