Cpped1 calcineurin-like phosphoesterase domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cpped1provided by RGD
Official Full Name: calcineurin-like phosphoesterase domain containing 1provided by RGD
Primary source: RGD:1306568
See related: AllianceGenome:RGD:1306568
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1306568
Summary: Predicted to enable metal ion binding activity and phosphoprotein phosphatase activity. Predicted to be involved in chromatin remodeling and regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and plasma membrane. Orthologous to human CPPED1 (calcineurin like phosphoesterase domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 97.0), Liver (RPKM 85.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (4135601..4328039)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (3701522..3821050)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (3655038..3774887)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BE107796 (e-PCR)
- UniSTS:247057

RH141784 (e-PCR)
- UniSTS:223777

RH142467 (e-PCR)
- UniSTS:231714

RH144561 (e-PCR)
- UniSTS:233806

RH133395 (e-PCR)
- UniSTS:216678

D10Cebr1 (e-PCR)
- UniSTS:518619

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables MAP kinase serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin-dependent protein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS140 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein phosphatase CPPED1

Names: calcineurin-like phosphoesterase domain-containing protein 1

NP_001013985.1

EC 3.1.3.16

XP_063124925.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013963.1 → NP_001013985.1 serine/threonine-protein phosphatase CPPED1

See identical proteins and their annotated locations for NP_001013985.1

Status: PROVISIONAL

Source sequence(s)

BC081991

UniProtKB/Swiss-Prot

Q66H71

UniProtKB/TrEMBL

A6K4G7

Conserved Domains (2) summary

COG1409
Location:33 → 268

CpdA; 3',5'-cyclic AMP phosphodiesterase CpdA [Signal transduction mechanisms]

cd07395
Location:29 → 294

MPP_CSTP1; Homo sapiens CSTP1 and related proteins, metallophosphatase domain