Ctrl chymotrypsin-like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ctrlprovided by RGD
Official Full Name: chymotrypsin-likeprovided by RGD
Primary source: RGD:621501
See related: EnsemblRapid:ENSRNOG00000019353 AllianceGenome:RGD:621501
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables serine-type peptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to act upstream of or within proteolysis. Predicted to be located in extracellular space. Predicted to be part of proteasome core complex. Orthologous to human CTRL (chymotrypsin like). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 1398.5) and Liver (RPKM 413.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (50737078..50740659, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (33827279..33829129, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (37905864..37907714, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

molecular cloning and characterization of chymopasin from the pancreas [chymopasin]
Title: Molecular cloning and characterization of chymopasin, a novel serine protease from rat pancreas.

Submit: New GeneRIF Correction

General gene information

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Markers

Ctrl (e-PCR), detects polymorphism
- UniSTS:531086

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type peptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within proteolysis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis involved in protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: chymotrypsin-like protease CTRL-1

Names: chymopasin

XP_063133810.1

EC 3.4.21.-

XP_063133811.1

EC 3.4.21.-

XP_063133812.1

EC 3.4.21.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_054009.2 → NP_446461.2 chymotrypsin-like protease CTRL-1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

A6IYU1, G3V8J3, Q9EQZ8