U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Birc5 baculoviral IAP repeat-containing 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64041, updated on 27-Nov-2024

    Summary

    Official Symbol
    Birc5provided by RGD
    Official Full Name
    baculoviral IAP repeat-containing 5provided by RGD
    Primary source
    RGD:70499
    See related
    EnsemblRapid:ENSRNOG00000050819 AllianceGenome:RGD:70499
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    AP14
    Summary
    Predicted to enable several functions, including cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protein dimerization activity; and small GTPase binding activity. Involved in several processes, including cellular response to ethanol; cellular response to stem cell factor stimulus; and response to glucocorticoid. Located in apical plasma membrane. Used to study endometriosis and pulmonary hypertension. Biomarker of acute pancreatitis (multiple); artery disease (multiple); congestive heart failure; high grade glioma; and stomach carcinoma. Human ortholog(s) of this gene implicated in prostate cancer and transitional cell carcinoma. Orthologous to human BIRC5 (baculoviral IAP repeat containing 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 156.5), Spleen (RPKM 102.8) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Birc5 in Genome Data Viewer
    Location:
    10q32.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (103567369..103580069)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (103072530..103081382)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (106856097..106864419)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene thymidine kinase 1 Neighboring gene arylformamidase Neighboring gene uncharacterized LOC102548046 Neighboring gene transmembrane protein 235 Neighboring gene threonine aldolase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tubulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in G2/M transition of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell division ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to stem cell factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of chromosome localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of chromosome localization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in meiosis I IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in meiosis I ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic cytokinesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitotic spindle assembly checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic spindle assembly checkpoint signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cysteine-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of exit from mitosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of exit from mitosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein-containing complex localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein-containing complex localization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of insulin secretion involved in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of type B pancreatic cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of type B pancreatic cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to glucocorticoid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to peptide hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of chromosome passenger complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of chromosome passenger complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of chromosome passenger complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome, centromeric region ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in interphase microtubule organizing center ISO
    Inferred from Sequence Orthology
    more info
     
    located_in interphase microtubule organizing center ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    located_in midbody ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of survivin complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    baculoviral IAP repeat-containing protein 5
    Names
    apoptosis inhibitor survivin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022274.2NP_071610.2  baculoviral IAP repeat-containing protein 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q9JHY7
      UniProtKB/TrEMBL
      A6HL35
      Conserved Domains (1) summary
      pfam00653
      Location:1888
      BIR; Inhibitor of Apoptosis domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      103567369..103580069
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269805.1XP_063125875.1  baculoviral IAP repeat-containing protein 5 isoform X1

      UniProtKB/TrEMBL
      M0R8I8
      Related
      ENSRNOP00000065784.2, ENSRNOT00000072387.3