IIL1 isopropyl malate isomerase large subunit 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: IIL1
Official Full Name: isopropyl malate isomerase large subunit 1
Primary source: TAIR:AT4G13430
Locus tag: AT4G13430
See related: Araport:AT4G13430
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATLEUC1; isopropyl malate isomerase large subunit 1; T9E8.170; T9E8_170
Summary: Encodes a methylthioalkylmalate isomerase involved in glucosinolate biosynthesis.
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Genomic context

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See IIL1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 15

Sequence:: Chromosome: 4; NC_003075.7 (7803863..7807984, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AtLeuC1 and AtIMD1 encode methylthioalkylmalate isomerase and methylthioalkylmalate dehydrogenase, respectively. These enzymes have roles in controlling metabolism from methionine to primary and methionine-related secondary metabolites. [AtLeuC1]
Title: Omics-based approaches to methionine side chain elongation in Arabidopsis: characterization of the genes encoding methylthioalkylmalate isomerase and methylthioalkylmalate dehydrogenase.
study identified a triplet repeat-associated genetic defect; Bur-0 strain has a dramatically expanded TTC/GAA repeat in the intron of the IIL1 (At4g13430) gene; repeat expansion causes an environment-dependent reduction in IIL1 activity & impairs growth
Title: A genetic defect caused by a triplet repeat expansion in Arabidopsis thaliana.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_117417.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables 3-isopropylmalate dehydratase activity	IEA Inferred from Electronic Annotation more info
enables intramolecular hydroxytransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in L-leucine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glucosinolate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast stroma	HDA more info	PubMed
located_in plastid	HDA more info	PubMed

General protein information

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Preferred Names: isopropyl malate isomerase large subunit 1

NP_567405.1

isopropyl malate isomerase large subunit 1 (IIL1); FUNCTIONS IN: lyase activity, intramolecular transferase activity, transferring hydroxy groups; INVOLVED IN: glucosinolate biosynthetic process, response to cadmium ion, metabolic process; LOCATED IN: chloroplast stroma, chloroplast; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha (InterPro:IPR001030), Homoaconitase/3-isopropylmalate dehydratase, small/large subunit (InterPro:IPR015936), Homoaconitase/3-isopropylmalate dehydratase, large subunit, subgroup (InterPro:IPR006251), Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2 (InterPro:IPR015932), Aconitase-like core (InterPro:IPR015937), Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 (InterPro:IPR015931); BEST Arabidopsis thaliana protein match is: aconitase 2 (TAIR:AT4G26970.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

7803863..7807984 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_117417.4 → NP_567405.1 isopropyl malate isomerase large subunit 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_567405.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q94AR8, Q9T0L4

UniProtKB/TrEMBL

A0A178UWP5, A0A5S9XS68

Conserved Domains (1) summary

cd01583
Location:95 → 501

IPMI; 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate