Pld1 phospholipase D1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pld1provided by RGD
Official Full Name: phospholipase D1provided by RGD
Primary source: RGD:3349
See related: EnsemblRapid:ENSRNOG00000028156 AllianceGenome:RGD:3349
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Plda; Pldb; Pld1a; Pld1b
Summary: Enables phospholipase D activity. Involved in phospholipid catabolic process; positive regulation of cell migration; and response to peptide hormone. Acts upstream of or within phosphatidic acid biosynthetic process. Located in Golgi cisterna; lamellipodium; and vesicle. Is active in synapse. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in developmental cardiac valvular defect. Orthologous to human PLD1 (phospholipase D1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 150.5), Lung (RPKM 47.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q24

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (112777820..112975857)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (110849205..111047304)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (113651967..113849403)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phospholipase D1 produces phosphatidic acid at sites of secretory vesicle docking and fusion.
Title: Phospholipase D1 produces phosphatidic acid at sites of secretory vesicle docking and fusion.
Phospholipase D1 promotes astrocytic differentiation through the FAK/AURKA/STAT3 signaling pathway in hippocampal neural stem/progenitor cells.
Title: Phospholipase D1 promotes astrocytic differentiation through the FAK/AURKA/STAT3 signaling pathway in hippocampal neural stem/progenitor cells.
PLD1 knockdown reduces metastasis and inflammation of fibroblast-like synoviocytes in rheumatoid arthritis by modulating NF-kappaB and Wnt/beta-catenin pathways.
Title: PLD1 knockdown reduces metastasis and inflammation of fibroblast-like synoviocytes in rheumatoid arthritis by modulating NF-κB and Wnt/β-catenin pathways.
Phospholipase D1 Ameliorates Apoptosis in Chronic Renal Toxicity Caused by Low-Dose Cadmium Exposure.
Title: Phospholipase D1 Ameliorates Apoptosis in Chronic Renal Toxicity Caused by Low-Dose Cadmium Exposure.
PLD1 directly interacts with PKD1. The enzymatic activity of PLD1 is required to promote dendritic spine development.
Title: PLD1 promotes dendritic spine morphogenesis via activating PKD1.
Increased expression of both Pld1 and Pld2 occurs simultaneously with the appearance of vascular calcification in chronic kidney disease.
Title: Phospholipase D: A new mediator during high phosphate-induced vascular calcification associated with chronic kidney disease.
our results indicate a positive role of PLD1 in synaptogenesis by inhibiting the ADAM10 mediated N-cadherin cleavage and provide new therapeutic clues for some neurological diseases.
Title: PLD1 promotes dendritic spine development by inhibiting ADAM10-mediated N-cadherin cleavage.
These results suggest that PLD1 activity regulates COPII vesicle transport from the endoplasmic reticulum (ER) to the Golgi apparatus by regulating Sec13/31 recruitment from the cytosol to the ER membrane during COPII vesicle formation.
Title: Inhibition of PLD1 activity causes ER stress via regulation of COPII vesicle formation.
During neuronal differentiation of neural stem cells, Pld1 is activated.
Title: Phospholipase D1 increases Bcl-2 expression during neuronal differentiation of rat neural stem cells.
Results show that TRPM8 and the 5-HT1BR interact directly in a novel signalling complex that incorporates PLD1, which mediates the facilitatory influence by means of its product phosphatidic acid acting on PIP 5-kinase to increase production of PIP2
Title: The TRPM8 channel forms a complex with the 5-HT(1B) receptor and phospholipase D that amplifies its reversal of pain hypersensitivity.

Submit: New GeneRIF Correction See all GeneRIFs (51)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables phospholipase D activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase D activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase D activity	IEA Inferred from Electronic Annotation more info
enables phospholipase D activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to nutrient	IEA Inferred from Electronic Annotation more info
involved_in cellular response to nutrient	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidic acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphatidic acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phospholipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in regulation of microvillus assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of microvillus assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of microvillus assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to peptide hormone	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi cisterna	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cholinergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in cholinergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in endocytic vesicle	IEA Inferred from Electronic Annotation more info
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phospholipase D1

Names: PLD 1; Phoshpolipase D gene 1 probably with two splicing variants A and B; choline phosphatase 1; phosphatidylcholine-hydrolyzing phospholipase D1; phospholipase D gene 1, probably with two splicing variants A and B; phospholipase D1, phosphatidylcholine-specific; rPLD1

NP_001386011.1

EC 3.1.4.4

NP_112254.2

EC 3.1.4.4

XP_006232268.1

EC 3.1.4.4

XP_063137387.1

EC 3.1.4.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399082.1 → NP_001386011.1 phospholipase D1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

O08959, O35856, O54765, P70496, P70497, Q9QWJ6

UniProtKB/TrEMBL

F1LMG4

Related

ENSRNOP00000034466.4, ENSRNOT00000039296.8

Conserved Domains (1) summary

PLN02866
Location:82 → 1059

PLN02866; phospholipase D
NM_030992.3 → NP_112254.2 phospholipase D1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A6IHH9, D4A318

Related

ENSRNOP00000035045.4, ENSRNOT00000039308.6

Conserved Domains (1) summary

PLN02866
Location:82 → 1021

PLN02866; phospholipase D