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    egg-6 Leucine-rich repeat-containing protein egg-6 [ Caenorhabditis elegans ]

    Gene ID: 172670, updated on 9-Dec-2024

    Summary

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    Official Symbol
    egg-6
    Official Full Name
    Leucine-rich repeat-containing protein egg-6
    Primary source
    WormBase:WBGene00010621
    Locus tag
    CELE_K07A12.2
    See related
    AllianceGenome:WB:WBGene00010621
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in cell development. Predicted to be located in apical plasma membrane. Is expressed in hypodermis; interfacial epithelial cell; neurons; pharynx; and vulva. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See egg-6 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (8676666..8681325, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Nulp1-pending protein Neighboring gene Ovule protein Neighboring gene ncRNA Neighboring gene Homolog of Odr-2 (Two) Neighboring gene Tr-type G domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Extracellular leucine-rich repeat proteins are required to organize the apical extracellular matrix and maintain epithelial junction integrity in C. elegans. Mancuso VP, et al. Development, 2012 Mar. PMID 22278925, Free PMC Article
    2. Germline inherited small RNAs facilitate the clearance of untranslated maternal mRNAs in C. elegans embryos. Quarato P, et al. Nat Commun, 2021 Mar 4. PMID 33664268, Free PMC Article
    3. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Leucine-rich repeat-containing protein egg-6
    NP_492348.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8676666..8681325 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059947.6 → NP_492348.1  Leucine-rich repeat-containing protein egg-6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492348.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P90920
      Conserved Domains (4) summary
      cd00116
      Location:240 → 458
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:437 → 449
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:201 → 224
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:365 → 425
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P90920.2

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