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    gly-19 C-type lectin domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172447, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gly-19
    Official Full Name
    C-type lectin domain-containing protein
    Primary source
    WormBase:WBGene00001644
    Locus tag
    CELE_F22D6.12
    See related
    AllianceGenome:WB:WBGene00001644
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glycosyltransferase activity. Predicted to be located in Golgi membrane. Is expressed in anal sphincter muscle and intestine. Human ortholog(s) of this gene implicated in cataract and cataract 13 with adult i phenotype. Orthologous to several human genes including GCNT1 (glucosaminyl (N-acetyl) transferase 1); GCNT3 (glucosaminyl (N-acetyl) transferase 3, mucin type); and GCNT4 (glucosaminyl (N-acetyl) transferase 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gly-19 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (7113017..7114982)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene GLYcosylation related Neighboring gene Inner membrane protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Complementary expression patterns of six nonessential Caenorhabditis elegans core 2/I N-acetylglucosaminyltransferase homologues. Warren CE, et al. Glycobiology, 2001 Nov. PMID 11744632
    2. Two sensory neurons coordinate the systemic mitochondrial stress response via GPCR signaling in C. elegans. Liu Y, et al. Dev Cell, 2022 Nov 7. PMID 36309009
    3. Carbohydrates and glycosylation. Berninsone PM. WormBook, 2006 Dec 18. PMID 18050430, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    C-type lectin domain-containing protein
    NP_492015.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7113017..7114982
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059614.7 → NP_492015.1  C-type lectin domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492015.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBK7, Q962C1
      Conserved Domains (1) summary
      pfam02485
      Location:116 → 320
      Branch; Core-2/I-Branching enzyme
    Nucleotide Protein
    Heading Accession and Version

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