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    fkb-5 peptidylprolyl isomerase [ Caenorhabditis elegans ]

    Gene ID: 171974, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fkb-5
    Official Full Name
    peptidylprolyl isomerase
    Primary source
    WormBase:WBGene00001430
    Locus tag
    CELE_C50F2.6
    See related
    AllianceGenome:WB:WBGene00001430
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to be active in endoplasmic reticulum. Is expressed in hypodermis. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 11. Orthologous to human FKBP10 (FKBP prolyl isomerase 10) and FKBP9 (FKBP prolyl isomerase 9). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fkb-5 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (3898050..3899802, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene Tyrosine-protein phosphatase domain-containing protein Neighboring gene Sialomucin core protein 24 Neighboring gene ncRNA Neighboring gene Guanylate kinase-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Caenorhabditis elegans parvulin gene subfamily and their expression under cold or heat stress along with the fkb subfamily. Fasseas MK, et al. Biochem Biophys Res Commun, 2012 Jul 6. PMID 22683625
    2. Loss of secretory pathway FK506-binding proteins results in cold-sensitive lethality and associate extracellular matrix defects in the nematode Caenorhabditis elegans. Winter AD, et al. J Biol Chem, 2007 Apr 27. PMID 17339317
    3. Sequence diversification of the FK506-binding proteins in several different genomes. Galat A. Eur J Biochem, 2000 Aug. PMID 10931176
    4. DAF-16-dependent and independent expression targets of DAF-2 insulin receptor-like pathway in Caenorhabditis elegans include FKBPs. Yu H, et al. J Mol Biol, 2001 Dec 14. PMID 11743719
    5. The Caenorhabditis elegans heterochronic regulator LIN-14 is a novel transcription factor that controls the developmental timing of transcription from the insulin/insulin-like growth factor gene ins-33 by direct DNA binding. Hristova M, et al. Mol Cell Biol, 2005 Dec. PMID 16314527, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    peptidylprolyl isomerase
    NP_001367683.1
    • Confirmed by transcript evidence
    NP_001370590.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3898050..3899802 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001384047.2 → NP_001370590.1  peptidylprolyl isomerase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91180
      Conserved Domains (1) summary
      pfam00254
      Location:43 → 135
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

    2. NM_001381792.1 → NP_001367683.1  peptidylprolyl isomerase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95Q60
      Conserved Domains (1) summary
      pfam00254
      Location:79 → 171
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    Nucleotide Protein
    Heading Accession and Version

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