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    taf-1 Bromo domain-containing protein;Transcription initiation factor TFIID subunit 1 [ Caenorhabditis elegans ]

    Gene ID: 173257, updated on 9-Dec-2024

    Summary

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    Official Symbol
    taf-1
    Official Full Name
    Bromo domain-containing protein;Transcription initiation factor TFIID subunit 1
    Primary source
    WormBase:WBGene00006382
    Locus tag
    CELE_W04A8.7
    See related
    AllianceGenome:WB:WBGene00006382
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable several functions, including RNA polymerase II general transcription initiation factor activity; TBP-class protein binding activity; and histone acetyltransferase activity. Predicted to contribute to transcription cis-regulatory region binding activity. Involved in embryo development and transcription initiation at RNA polymerase II promoter. Located in nucleus. Human ortholog(s) of this gene implicated in X-linked dystonia-parkinsonism and syndromic X-linked intellectual disability. Orthologous to several human genes including TAF1L (TATA-box binding protein associated factor 1 like). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See taf-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    15
    Sequence:
    Chromosome: I; NC_003279.8 (13861474..13887640)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene FBA_2 domain-containing protein Neighboring gene ncRNA Neighboring gene ANK_REP_REGION domain-containing protein Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A complex containing the O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 regulates GABA neuron function. Giles AC, et al. J Biol Chem, 2019 Apr 26. PMID 30858176, Free PMC Article
    2. Distinct requirements for C.elegans TAF(II)s in early embryonic transcription. Walker AK, et al. EMBO J, 2001 Sep 17. PMID 11566890, Free PMC Article
    3. An extensive requirement for transcription factor IID-specific TAF-1 in Caenorhabditis elegans embryonic transcription. Walker AK, et al. J Biol Chem, 2004 Apr 9. PMID 14726532
    4. Regulation of tissue-specific and extracellular matrix-related genes by a class I histone deacetylase. Whetstine JR, et al. Mol Cell, 2005 May 13. PMID 15893731
    5. Transcription mechanisms. Blackwell TK, et al. WormBook, 2006 Sep 5. PMID 18050436, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. during C. elegans embryogenesis TAF-1 and TFIID have broad roles in transcription and development
      Title: An extensive requirement for transcription factor IID-specific TAF-1 in Caenorhabditis elegans embryonic transcription.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II general transcription initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables TBP-class protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables TBP-class protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    contributes_to transcription cis-regulatory region binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA polymerase II preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIID complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIID complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Bromo domain-containing protein;Transcription initiation factor TFIID subunit 1
    NP_001391087.1
    • Confirmed by transcript evidence
    NP_493426.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      13861474..13887640
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061025.6 → NP_493426.2  Transcription initiation factor TFIID subunit 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493426.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EGM3
      Conserved Domains (3) summary
      cd05511
      Location:1413 → 1524
      Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
      pfam12157
      Location:489 → 947
      DUF3591; Protein of unknown function (DUF3591)
      pfam15288
      Location:1217 → 1251
      zf-CCHC_6; Zinc knuckle

    2. NM_001404219.1 → NP_001391087.1  Bromo domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8S4Q965
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EGM3.1

    Gene LinkOut

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