oatr-1 putative ornithine aminotransferase, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: oatr-1
Official Full Name: putative ornithine aminotransferase, mitochondrial
Primary source: WormBase:WBGene00015814
Locus tag: CELE_C16A3.10
See related: AllianceGenome:WB:WBGene00015814
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable identical protein binding activity; ornithine aminotransferase activity; and pyridoxal phosphate binding activity. Predicted to be involved in arginine catabolic process to glutamate and arginine catabolic process to proline via ornithine. Predicted to be located in mitochondrial matrix. Predicted to be active in cytoplasm. Is expressed in hypodermis; intestine; nervous system; pharynx; and tail. Used to study amino acid metabolic disorder. Human ortholog(s) of this gene implicated in gyrate atrophy. Orthologous to human OAT (ornithine aminotransferase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See oatr-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 6

Sequence:: Chromosome: III; NC_003281.10 (6394238..6395935, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C16A3.10 (e-PCR)
- UniSTS:309088

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables identical protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables ornithine aminotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ornithine aminotransferase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables transaminase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-proline biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in arginine catabolic process to glutamate	IBA Inferred from Biological aspect of Ancestor more info
involved_in arginine catabolic process to proline via ornithine	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative ornithine aminotransferase, mitochondrial

NP_741194.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

6394238..6395935 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171877.6 → NP_741194.1 putative ornithine aminotransferase, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741194.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q18040

Conserved Domains (2) summary

TIGR00707
Location:35 → 411

argD; transaminase, acetylornithine/succinylornithine family

cl18945
Location:21 → 415

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...