ida-1 Receptor-type tyrosine-protein phosphatase-like ida-1 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: ida-1
Official Full Name: Receptor-type tyrosine-protein phosphatase-like ida-1
Primary source: WormBase:WBGene00002048
Locus tag: CELE_B0244.2
See related: AllianceGenome:WB:WBGene00002048
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable transmembrane receptor protein tyrosine phosphatase activity. Involved in positive regulation of anterior/posterior axon guidance; positive regulation of neurotransmitter secretion; and ventral cord development. Located in dense core granule and synapse. Is expressed in several structures, including buccal cavity; egg-laying apparatus; neurons; preanal ganglion; and somatic nervous system. Used to study Parkinson's disease and diabetes mellitus. Human ortholog(s) of this gene implicated in prediabetes syndrome and type 1 diabetes mellitus. Orthologous to several human genes including PTPRN2 (protein tyrosine phosphatase receptor type N2). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See ida-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 12

Sequence:: Chromosome: III; NC_003281.10 (5755539..5765816)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show the function of membrane glycoprotein ida-1 as a modulator in insulin receptor Daf-2/transcription factor Daf-16 insulin like signalling pathway thus possibly being a common link between Parkinson's disease and diabetes.
Title: Ida-1, the Caenorhabditis elegans orthologue of mammalian diabetes autoantigen IA-2, potentially acts as a common modulator between Parkinson's disease and Diabetes: role of Daf-2/Daf-16 insulin like signalling pathway.
Loss of PAG-3 results in up-regulation of IDA-1 and other dense core vesicle proteins.
Title: Loss of the transcriptional repressor PAG-3/Gfi-1 results in enhanced neurosecretion that is dependent on the dense-core vesicle membrane protein IDA-1/IA-2.
Using two null alleles of ida-1[=CeIA-2], we demonstrate that animals lacking CeIA-2 activity are viable but exhibit subtle defects; CeIA-2 loss enhances weak alleles in the insulin-like signaling pathway and reveals genetic interaction with UNC-31/CAPS
Title: Insulinoma-Associated Protein IA-2, a Vesicle Transmembrane Protein, Genetically Interacts with UNC-31/CAPS and Affects Neurosecretion in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

B0244.2 (e-PCR)
- UniSTS:313372

STS3-146 (e-PCR)
- UniSTS:241986

B0244.3 (e-PCR)
- UniSTS:315299

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in exocytosis	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of anterior/posterior axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in ventral cord development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dense core granule	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info
located_in secretory granule	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network transport vesicle	TAS Traceable Author Statement more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: Receptor-type tyrosine-protein phosphatase-like ida-1

NP_498245.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

5755539..5765816

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065844.7 → NP_498245.2 Receptor-type tyrosine-protein phosphatase-like ida-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498245.2

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EGJ5

Conserved Domains (1) summary

cd00047
Location:529 → 755

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...