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    nhr-68 NR LBD domain-containing protein;Nuclear hormone receptor family member nhr-68 [ Caenorhabditis elegans ]

    Gene ID: 179589, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nhr-68
    Official Full Name
    NR LBD domain-containing protein;Nuclear hormone receptor family member nhr-68
    Primary source
    WormBase:WBGene00003658
    Locus tag
    CELE_H12C20.3
    See related
    AllianceGenome:WB:WBGene00003658
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of transcription by RNA polymerase II. Located in chromatin. Is expressed in head muscle; head neurons; hypodermis; and intestine. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nhr-68 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (11573440..11575709)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Mismatch repair endonuclease PMS2 Neighboring gene Nuclear Hormone Receptor family Neighboring gene Uncharacterized protein Neighboring gene pseudo Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Persistence Detector for Metabolic Network Rewiring in an Animal. Bulcha JT, et al. Cell Rep, 2019 Jan 8. PMID 30625328, Free PMC Article
    2. Transcription Factor Activity Mapping of a Tissue-Specific in vivo Gene Regulatory Network. MacNeil LT, et al. Cell Syst, 2015 Aug 26. PMID 26430702, Free PMC Article
    3. A D-2-hydroxyglutarate dehydrogenase mutant reveals a critical role for ketone body metabolism in Caenorhabditis elegans development. Ponomarova O, et al. PLoS Biol, 2023 Apr. PMID 37043428, Free PMC Article
    4. Caenorhabditis elegans methionine/S-adenosylmethionine cycle activity is sensed and adjusted by a nuclear hormone receptor. Giese GE, et al. Elife, 2020 Oct 5. PMID 33016879, Free PMC Article
    5. Integration of metabolic and gene regulatory networks modulates the C. elegans dietary response. Watson E, et al. Cell, 2013 Mar 28. PMID 23540702, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of propionate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NR LBD domain-containing protein;Nuclear hormone receptor family member nhr-68
    NP_001366648.1
    • Confirmed by transcript evidence
    NP_001368113.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11573440..11575709
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001380769.3 → NP_001366648.1  Nuclear hormone receptor family member nhr-68 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86PK1, Q9XXM8
      Conserved Domains (2) summary
      cd06960
      Location:7 → 82
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
      smart00430
      Location:193 → 354
      HOLI; Ligand binding domain of hormone receptors

    2. NM_001380770.1 → NP_001368113.1  NR LBD domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H8ESE6
      Conserved Domains (1) summary
      cl11397
      Location:1 → 65
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XXM8.1

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