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    rps-3 Small ribosomal subunit protein uS3 [ Caenorhabditis elegans ]

    Gene ID: 175879, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rps-3
    Official Full Name
    Small ribosomal subunit protein uS3
    Primary source
    WormBase:WBGene00004472
    Locus tag
    CELE_C23G10.3
    See related
    AllianceGenome:WB:WBGene00004472
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to be involved in positive regulation of apoptotic signaling pathway. Predicted to be located in ribosome. Predicted to be part of cytosolic small ribosomal subunit. Predicted to be active in nucleus. Orthologous to human RPS3 (ribosomal protein S3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rps-3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (6206803..6207965)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene 26S proteasome non-ATPase regulatory subunit 1 Neighboring gene NADAR domain-containing protein Neighboring gene RutC family protein C23G10.2 Neighboring gene Serine/threonine-protein phosphatase C23G10.1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans ribosomal protein S3 protects against H(2)O(2)-induced DNA damage and suppresses spontaneous mutations in yeast. Elsakrmy N, et al. DNA Repair (Amst), 2022 Sep. PMID 35809390
    2. Caenorhabditis elegans evolves a new architecture for the multi-aminoacyl-tRNA synthetase complex. Havrylenko S, et al. J Biol Chem, 2011 Aug 12. PMID 21685384, Free PMC Article
    3. Lifespan regulation by evolutionarily conserved genes essential for viability. Curran SP, et al. PLoS Genet, 2007 Apr 6. PMID 17411345, Free PMC Article
    4. Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network. Tewari M, et al. Mol Cell, 2004 Feb 27. PMID 14992718
    5. The nascent polypeptide-associated complex is a key regulator of proteostasis. Kirstein-Miles J, et al. EMBO J, 2013 May 15. PMID 23604074, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Small ribosomal subunit protein uS3
    NP_498349.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6206803..6207965
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065948.6 → NP_498349.1  Small ribosomal subunit protein uS3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498349.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48152
      Conserved Domains (3) summary
      cd02413
      Location:17 → 97
      40S_S3_KH; K homology RNA-binding (KH) domain of the eukaryotic 40S small ribosomal subunit protein S3. S3 is part of the head region of the 40S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH ...
      PTZ00084
      Location:5 → 218
      PTZ00084; 40S ribosomal protein S3; Provisional
      pfam00189
      Location:107 → 188
      Ribosomal_S3_C; Ribosomal protein S3, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48152.1

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