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    zig-4 Zwei Ig domain protein zig-4 [ Caenorhabditis elegans ]

    Gene ID: 181051, updated on 9-Dec-2024

    Summary

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    Official Symbol
    zig-4
    Official Full Name
    Zwei Ig domain protein zig-4
    Primary source
    WormBase:WBGene00006981
    Locus tag
    CELE_C09C7.1
    See related
    AllianceGenome:WB:WBGene00006981
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in neuron development. Predicted to be located in extracellular region. Is expressed in nervous system and pharynx. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See zig-4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    3
    Sequence:
    Chromosome: X; NC_003284.9 (7925434..7926595)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Chitin-binding type-2 domain-containing protein Neighboring gene ncRNA Neighboring gene Zwei Ig domain protein zig-3 Neighboring gene TropoNin T;Troponin T

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of spatial and temporal cues that regulate postembryonic expression of axon maintenance factors in the C. elegans ventral nerve cord. Aurelio O, et al. Development, 2003 Feb. PMID 12490565
    2. Differential functions of the C. elegans FGF receptor in axon outgrowth and maintenance of axon position. Bülow HE, et al. Neuron, 2004 May 13. PMID 15134634
    3. The C. elegans F-spondin family protein SPON-1 maintains cell adhesion in neural and non-neural tissues. Woo WM, et al. Development, 2008 Aug. PMID 18614580, Free PMC Article
    4. Immunoglobulin-domain proteins required for maintenance of ventral nerve cord organization. Aurelio O, et al. Science, 2002 Jan 25. PMID 11809975
    5. Molecular encoding of stimulus features in a single sensory neuron type enables neuronal and behavioral plasticity. Harris N, et al. Curr Biol, 2023 Apr 24. PMID 36977417, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Double mutant analysis shows that zig-3 and zig-4 act together to affect axon maintenance, yet they are not functionally interchangeable.
      Title: The small, secreted immunoglobulin protein ZIG-3 maintains axon position in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in neuron development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Zwei Ig domain protein zig-4
    NP_509335.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      7925434..7926595
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076934.7 → NP_509335.1  Zwei Ig domain protein zig-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509335.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5ECB1
      Conserved Domains (4) summary
      cd00096
      Location:65 → 144
      Ig; Immunoglobulin domain
      smart00410
      Location:176 → 245
      IG_like; Immunoglobulin like
      pfam07679
      Location:47 → 147
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:193 → 238
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5ECB1.1

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