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    phdh-1 D-3-phosphoglycerate dehydrogenase [ Caenorhabditis elegans ]

    Gene ID: 175012, updated on 9-Dec-2024

    Summary

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    Official Symbol
    phdh-1
    Official Full Name
    D-3-phosphoglycerate dehydrogenase
    Primary source
    WormBase:WBGene00007836
    Locus tag
    CELE_C31C9.2
    See related
    AllianceGenome:WB:WBGene00007836
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phosphoglycerate dehydrogenase activity. Is expressed in hypodermis; intestine; nervous system; and pharynx. Human ortholog(s) of this gene implicated in Neu-Laxova syndrome 1; PHGDH deficiency; and amino acid metabolic disorder. Orthologous to human PHGDH (phosphoglycerate dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See phdh-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003280.10 (13636869..13638480, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Glutathione S-Transferase Neighboring gene GST C-terminal domain-containing protein Neighboring gene Glutathione S-transferase Neighboring gene DPPIV_N domain-containing protein;Protein TolB;Translocation protein TolB Neighboring gene F-box domain-containing protein Neighboring gene pseudo Neighboring gene F-box domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The effect of repeated isoflurane exposure on serine synthesis pathway during the developmental period in Caenorhabditis elegans. Do SH, et al. Neurotoxicology, 2019 Mar. PMID 30639121
    2. Mitochondrial protein import determines lifespan through metabolic reprogramming and de novo serine biosynthesis. Lionaki E, et al. Nat Commun, 2022 Feb 3. PMID 35115503, Free PMC Article
    3. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
    4. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article
    5. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoglycerate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    D-3-phosphoglycerate dehydrogenase
    NP_001408274.1
    • Confirmed by transcript evidence
    NP_496868.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      13636869..13638480 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064467.6 → NP_496868.1  D-3-phosphoglycerate dehydrogenase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496868.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17626
      Conserved Domains (2) summary
      COG0111
      Location:4 → 309
      SerA; Phosphoglycerate dehydrogenase or related dehydrogenase [Coenzyme transport and metabolism, General function prediction only]
      cd12173
      Location:7 → 309
      PGDH_4; Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains

    2. NM_001421351.1 → NP_001408274.1  D-3-phosphoglycerate dehydrogenase [Caenorhabditis elegans]

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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