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    ttb-1 Transcription initiation factor IIB [ Caenorhabditis elegans ]

    Gene ID: 178544, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ttb-1
    Official Full Name
    Transcription initiation factor IIB
    Primary source
    WormBase:WBGene00006648
    Locus tag
    CELE_W03F9.5
    See related
    AllianceGenome:WB:WBGene00006648
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA polymerase II general transcription initiation factor activity and TBP-class protein binding activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly and transcriptional start site selection at RNA polymerase II promoter. Predicted to be part of transcription preinitiation complex. Predicted to be active in nucleus. Orthologous to human GTF2B (general transcription factor IIB). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ttb-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (156825..166866)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class H Neighboring gene Choline/carnitine acyltransferase domain-containing protein Neighboring gene Cilia- and flagella-associated protein 36 Neighboring gene Pre-mRNA-splicing factor 38 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Caenorhabditis elegans mRNA 5'-capping enzyme. In vitro and in vivo characterization. Takagi T, et al. J Biol Chem, 2003 Apr 18. PMID 12576476
    2. Broad requirement for the mediator subunit RGR-1 for transcription in the Caenorhabditis elegans embryo. Shim EY, et al. J Biol Chem, 2002 Aug 23. PMID 12089139
    3. Caenorhabditis elegans mediator complexes are required for developmental-specific transcriptional activation. Kwon JY, et al. Proc Natl Acad Sci U S A, 1999 Dec 21. PMID 10611325, Free PMC Article
    4. Distinct requirements for C.elegans TAF(II)s in early embryonic transcription. Walker AK, et al. EMBO J, 2001 Sep 17. PMID 11566890, Free PMC Article
    5. An extensive requirement for transcription factor IID-specific TAF-1 in Caenorhabditis elegans embryonic transcription. Walker AK, et al. J Biol Chem, 2004 Apr 9. PMID 14726532

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables TBP-class protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables TBP-class protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA-templated transcription initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA polymerase II preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription preinitiation complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcriptional start site selection at RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Transcription initiation factor IIB
    NP_503146.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      156825..166866
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070745.5 → NP_503146.1  Transcription initiation factor IIB [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503146.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16991
      Conserved Domains (3) summary
      COG1405
      Location:6 → 285
      SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
      pfam00382
      Location:111 → 181
      TFIIB; Transcription factor TFIIB repeat
      pfam08271
      Location:6 → 45
      TF_Zn_Ribbon; TFIIB zinc-binding
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O16991.2

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