dld-1 Dihydrolipoyl dehydrogenase, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dld-1
Official Full Name: Dihydrolipoyl dehydrogenase, mitochondrial
Primary source: WormBase:WBGene00010794
Locus tag: CELE_LLC1.3
See related: AllianceGenome:WB:WBGene00010794
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable dihydrolipoyl dehydrogenase activity and flavin adenine dinucleotide binding activity. Predicted to be involved in 2-oxoglutarate metabolic process and pyruvate metabolic process. Predicted to be located in mitochondrial matrix. Predicted to be part of oxoglutarate dehydrogenase complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in maple syrup urine disease. Orthologous to human DLD (dihydrolipoamide dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dld-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 8

Sequence:: Chromosome: IV; NC_003282.8 (14464517..14469136)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Attenuation of radiation toxicity by the phosphine resistance factor dihydrolipoamide dehydrogenase (DLD).
Title: Attenuation of radiation toxicity by the phosphine resistance factor dihydrolipoamide dehydrogenase (DLD).
study found polymorphisms responsible for genetic resistance to phosphine gas cluster around the redox-active catalytic disulfide or the dimerization interface of dihydrolipoamide dehydrogenase; also mutation of DLD increases arsenite sensitivity
Title: A core metabolic enzyme mediates resistance to phosphine gas.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

LLC1.3 (e-PCR)
- UniSTS:311941

LLC1.2 (e-PCR)
- UniSTS:322244

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables dihydrolipoyl dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dihydrolipoyl dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 2-oxoglutarate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in pyruvate metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of oxoglutarate dehydrogenase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Dihydrolipoyl dehydrogenase, mitochondrial

NP_001255810.1

Confirmed by transcript evidence

NP_001255811.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

14464517..14469136

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001268881.2 → NP_001255810.1 Dihydrolipoyl dehydrogenase, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255810.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3YT81, O17953

Conserved Domains (4) summary

PRK06327
Location:27 → 486

PRK06327; dihydrolipoamide dehydrogenase; Validated

pfam00070
Location:201 → 279

Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase

pfam02852
Location:375 → 481

Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain

cl21454
Location:29 → 66

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_001268882.3 → NP_001255811.1 Dihydrolipoyl dehydrogenase, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255811.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O17953

Conserved Domains (1) summary

pfam02852
Location:30 → 136

Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain