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    gst-44 Glutathione S-transferase omega [ Caenorhabditis elegans ]

    Gene ID: 184405, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gst-44
    Official Full Name
    Glutathione S-transferase omega
    Primary source
    WormBase:WBGene00001792
    Locus tag
    CELE_F13A7.10
    See related
    AllianceGenome:WB:WBGene00001792
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glutathione dehydrogenase (ascorbate) activity and glutathione transferase activity. Involved in response to reactive oxygen species. Predicted to be active in cytoplasm. Is expressed in excretory cell. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and asthma. Orthologous to human GSTO1 (glutathione S-transferase omega 1) and GSTO2 (glutathione S-transferase omega 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gst-44 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (16390891..16392490)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class H Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene Serpentine receptor class delta-63 Neighboring gene Ubiquitinyl hydrolase 1 Neighboring gene Methyltransferase FkbM domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Insecticidal activity and mechanism of cinnamaldehyde in C. elegans. Lu L, et al. Fitoterapia, 2020 Oct. PMID 32681860
    2. The glutathione reductase GSR-1 determines stress tolerance and longevity in Caenorhabditis elegans. Lüersen K, et al. PLoS One, 2013. PMID 23593298, Free PMC Article
    3. Differential expression of genes in C. elegans reveals transcriptional responses to indirect-acting xenobiotic compounds and insensitivity to 2,3,7,8-tetrachlorodibenzodioxin. Karengera A, et al. Ecotoxicol Environ Saf, 2022 Mar 15. PMID 35219257
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables glutathione dehydrogenase (ascorbate) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione dehydrogenase (ascorbate) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylarsonate reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to reactive oxygen species IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Glutathione S-transferase omega
    NP_507142.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      16390891..16392490
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074741.4 → NP_507142.2  Glutathione S-transferase omega [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507142.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45352
      Conserved Domains (3) summary
      COG0625
      Location:29 → 229
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cl00388
      Location:8 → 98
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
      cl02776
      Location:112 → 245
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
    Nucleotide Protein
    Heading Accession and Version

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