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    tag-290 BPTI/Kunitz inhibitor domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179593, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tag-290
    Official Full Name
    BPTI/Kunitz inhibitor domain-containing protein
    Primary source
    WormBase:WBGene00009386
    Locus tag
    CELE_F35B12.6
    See related
    AllianceGenome:WB:WBGene00009386
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Is expressed in arcade cell and pharynx. Human ortholog(s) of this gene implicated in several diseases, including factor VIII deficiency; leukemia (multiple); osteonecrosis; thrombophilia (multiple); and toxic shock syndrome. Orthologous to human TFPI (tissue factor pathway inhibitor) and TFPI2 (tissue factor pathway inhibitor 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tag-290 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    2
    Sequence:
    Chromosome: V; NC_003283.11 (11613307..11614888)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene BPTI/Kunitz inhibitor domain-containing protein Neighboring gene ncRNA Neighboring gene Spindle assembly abnormal protein 5 Neighboring gene Neuropeptide-Like Protein Neighboring gene Globin family profile domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of an H3K9me anchor rescues laminopathy-linked changes in nuclear organization and muscle function in an Emery-Dreifuss muscular dystrophy model. Harr JC, et al. Genes Dev, 2020 Apr 1. PMID 32139421, Free PMC Article
    2. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    BPTI/Kunitz inhibitor domain-containing protein
    NP_505945.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11613307..11614888
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073544.5 → NP_505945.1  BPTI/Kunitz inhibitor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505945.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20014
      Conserved Domains (2) summary
      smart00131
      Location:156 → 211
      KU; BPTI/Kunitz family of serine protease inhibitors
      pfam00014
      Location:19 → 73
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    Nucleotide Protein
    Heading Accession and Version

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