ntr-1 G-protein coupled receptors family 1 profile domain-containing protein;Nematocin receptor 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ntr-1
Official Full Name: G-protein coupled receptors family 1 profile domain-containing protein;Nematocin receptor 1
Primary source: WormBase:WBGene00011582
Locus tag: CELE_T07D10.2
See related: AllianceGenome:WB:WBGene00011582
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be active in membrane. Is expressed in intestine and neurons. Human ortholog(s) of this gene implicated in autism spectrum disorder; hypertension; mood disorder (multiple); nephrogenic diabetes insipidus (multiple); and nephrogenic syndrome of inappropriate antidiuresis. Orthologous to several human genes including AVPR1A (arginine vasopressin receptor 1A); AVPR1B (arginine vasopressin receptor 1B); and AVPR2 (arginine vasopressin receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ntr-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 7

Sequence:: Chromosome: I; NC_003279.8 (12615921..12624241)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ntc-1 encodes a VP/OT-related peptide, nematocin, that signals through the NTR-1 receptor.[NTR-1]
Title: Vasopressin/oxytocin-related signaling regulates gustatory associative learning in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T07D10.2 (e-PCR)
- UniSTS:307965

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in behavior	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: G-protein coupled receptors family 1 profile domain-containing protein;Nematocin receptor 1

NP_001360454.1

Confirmed by transcript evidence

NP_493193.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

12615921..12624241

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001373647.2 → NP_001360454.1 G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A486WV28

Conserved Domains (1) summary

cd15196
Location:53 → 361

7tmA_Vasopressin_Oxytocin; vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_060792.2 → NP_493193.1 Nematocin receptor 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_493193.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O02300

Conserved Domains (1) summary

pfam00001
Location:61 → 340

7tm_1; 7 transmembrane receptor (rhodopsin family)