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    rev-1 DNA repair protein REV1 [ Caenorhabditis elegans ]

    Gene ID: 174275, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rev-1
    Official Full Name
    DNA repair protein REV1
    Primary source
    WormBase:WBGene00014066
    Locus tag
    CELE_ZK675.2
    See related
    AllianceGenome:WB:WBGene00014066
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-directed DNA polymerase activity and deoxycytidyl transferase activity. Predicted to be involved in error-free translesion synthesis and error-prone translesion synthesis. Predicted to be located in nucleus. Is expressed in intestine; neurons; and vm1. Orthologous to human REV1 (REV1 DNA directed polymerase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rev-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    11
    Sequence:
    Chromosome: II; NC_003280.10 (7900622..7904667)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Protein patched homolog 1;SSD domain-containing protein Neighboring gene ncRNA Neighboring gene Bestrophin homolog Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene F-BAR domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Combined loss of three DNA damage response pathways renders C. elegans intolerant to light. van Bostelen I, et al. DNA Repair (Amst), 2017 Jun. PMID 28472716
    2. Nucleotide Excision Repair, XPA-1, and the Translesion Synthesis Complex, POLZ-1 and REV-1, Are Critical for Interstrand Cross-Link Repair in Caenorhabditis elegans Germ Cells. Oh S, et al. Biochemistry, 2020 Sep 29. PMID 32945661, Free PMC Article
    3. A broad requirement for TLS polymerases η and κ, and interacting sumoylation and nuclear pore proteins, in lesion bypass during C. elegans embryogenesis. Roerink SF, et al. PLoS Genet, 2012 Jun. PMID 22761594, Free PMC Article
    4. Checkpoint silencing during the DNA damage response in Caenorhabditis elegans embryos. Holway AH, et al. J Cell Biol, 2006 Mar 27. PMID 16549501, Free PMC Article
    5. Identification of novel target genes of CeTwist and CeE/DA. Wang P, et al. Dev Biol, 2006 May 15. PMID 16480708

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deoxycytidyl transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in error-free translesion synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in error-prone translesion synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in error-prone translesion synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA repair protein REV1
    NP_495663.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7900622..7904667
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063262.4 → NP_495663.1  DNA repair protein REV1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495663.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q09615
      Conserved Domains (3) summary
      cd01701
      Location:381 → 802
      PolY_Rev1; DNA polymerase Rev1
      COG0389
      Location:440 → 809
      DinP; Nucleotidyltransferase/DNA polymerase involved in DNA repair [Replication, recombination and repair]
      pfam00533
      Location:251 → 326
      BRCT; BRCA1 C Terminus (BRCT) domain
    Nucleotide Protein
    Heading Accession and Version

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