pfd-6 putative prefoldin subunit 6 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pfd-6
Official Full Name: putative prefoldin subunit 6
Primary source: WormBase:WBGene00009004
Locus tag: CELE_F21C3.5
See related: AllianceGenome:WB:WBGene00009004
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein-folding chaperone binding activity. Predicted to be involved in chaperone-mediated protein complex assembly and protein folding. Located in cytoplasm. Is expressed in body wall musculature; hypodermal cell; intestinal cell; muscle cell; and neurons. Orthologous to human PFDN6 (prefoldin subunit 6). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pfd-6 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 4

Sequence:: Chromosome: I; NC_003279.8 (7282964..7283762, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

prefoldin 6 (PFD-6), a component of the molecular chaperone prefoldin-like complex, relays longevity response from HSF-1 to FOXO under reduced IIS.
Title: Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F21C3.6 (e-PCR)
- UniSTS:319265

F21C3.5 (e-PCR)
- UniSTS:320712

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein-folding chaperone binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chaperone-mediated protein complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of prefoldin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of prefoldin complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative prefoldin subunit 6

NP_492058.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

7282964..7283762 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059657.6 → NP_492058.1 putative prefoldin subunit 6 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492058.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P52554

Conserved Domains (1) summary

cd00632
Location:7 → 111

Prefoldin_beta; Prefoldin beta; Prefoldin is a hexameric molecular chaperone complex, composed of two evolutionarily related subunits (alpha and beta), which are found in both eukaryotes and archaea. Prefoldin binds and stabilizes newly synthesized polypeptides ...