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    gst-22 Glutathione S-Transferase [ Caenorhabditis elegans ]

    Gene ID: 180088, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gst-22
    Official Full Name
    Glutathione S-Transferase
    Primary source
    WormBase:WBGene00001770
    Locus tag
    CELE_F21H7.1
    See related
    AllianceGenome:WB:WBGene00001770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glutathione transferase activity. Predicted to be involved in glutathione metabolic process. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gst-22 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    2
    Sequence:
    Chromosome: V; NC_003283.11 (16231032..16232282, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Transmembrane protein Neighboring gene Calpain catalytic domain-containing protein Neighboring gene Transmembrane protein Neighboring gene Serpentine Receptor, class E (Epsilon) Neighboring gene C-type lectin domain-containing protein Neighboring gene Serpentine Receptor, class H

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide analysis reveals novel genes essential for heme homeostasis in Caenorhabditis elegans. Severance S, et al. PLoS Genet, 2010 Jul 29. PMID 20686661, Free PMC Article
    2. Host CDK-1 and formin mediate microvillar effacement induced by enterohemorrhagic Escherichia coli. Huang CR, et al. Nat Commun, 2021 Jan 4. PMID 33397943, Free PMC Article
    3. Life span and stress resistance of Caenorhabditis elegans are differentially affected by glutathione transferases metabolizing 4-hydroxynon-2-enal. Ayyadevara S, et al. Mech Ageing Dev, 2007 Feb. PMID 17157356, Free PMC Article
    4. Predicting PDZ domain-peptide interactions from primary sequences. Chen JR, et al. Nat Biotechnol, 2008 Sep. PMID 18711339, Free PMC Article
    5. CEST-2.2 overexpression alters lipid metabolism and extends longevity of mitochondrial mutants. Piazzesi A, et al. EMBO Rep, 2022 May 4. PMID 35297148, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Glutathione S-Transferase
    NP_507095.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      16231032..16232282 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074694.7 → NP_507095.1  Glutathione S-Transferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507095.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45387
      Conserved Domains (3) summary
      PTZ00057
      Location:6 → 213
      PTZ00057; glutathione s-transferase; Provisional
      cd03192
      Location:92 → 200
      GST_C_Sigma_like; C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases
      cd03039
      Location:4 → 82
      GST_N_Sigma_like; GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of ...
    Nucleotide Protein
    Heading Accession and Version

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