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    alh-4 Aldehyde dehydrogenase [ Caenorhabditis elegans ]

    Gene ID: 179026, updated on 9-Dec-2024

    Summary

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    Official Symbol
    alh-4
    Official Full Name
    Aldehyde dehydrogenase
    Primary source
    WormBase:WBGene00000110
    Locus tag
    CELE_T05H4.13
    See related
    AllianceGenome:WB:WBGene00000110
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in cellular aldehyde metabolic process. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in hypodermis and intestine. Human ortholog(s) of this gene implicated in Sjogren-Larsson syndrome and arteriosclerosis. Orthologous to several human genes including ALDH3A1 (aldehyde dehydrogenase 3 family member A1); ALDH3A2 (aldehyde dehydrogenase 3 family member A2); and ALDH3B1 (aldehyde dehydrogenase 3 family member B1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See alh-4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (6427208..6429920, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene DUF4706 domain-containing protein Neighboring gene ATP synthase-coupling factor 6, mitochondrial Neighboring gene Gastrulation defective protein 1 Neighboring gene Eukaryotic peptide chain release factor subunit 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Endocrine pheromones couple fat rationing to dauer diapause through HNF4α nuclear receptors. Gao C, et al. Sci China Life Sci, 2021 Dec. PMID 34755252
    2. Nuclear receptors NHR-49 and NHR-79 promote peroxisome proliferation to compensate for aldehyde dehydrogenase deficiency in C. elegans. Zeng L, et al. PLoS Genet, 2021 Jul. PMID 34237064, Free PMC Article
    3. CCAR-1 works together with the U2AF large subunit UAF-1 to regulate alternative splicing. Lugano DI, et al. RNA Biol, 2024 Jan. PMID 38126797, Free PMC Article
    4. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    5. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nuclear receptors NHR-49 and NHR-79 promote peroxisome proliferation to compensate for aldehyde dehydrogenase deficiency in C. elegans.
      Title: Nuclear receptors NHR-49 and NHR-79 promote peroxisome proliferation to compensate for aldehyde dehydrogenase deficiency in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables aldehyde dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aldehyde metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in aldehyde metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Aldehyde dehydrogenase
    NP_001360568.1
    • Partially confirmed by transcript evidence
    NP_504634.2
    • Partially confirmed by transcript evidence
    NP_741553.1
    • Confirmed by transcript evidence
    NP_741554.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      6427208..6429920 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072233.7 → NP_504634.2  Aldehyde dehydrogenase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504634.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86S57
      Conserved Domains (1) summary
      cd07087
      Location:5 → 430
      ALDH_F3-13-14_CALDH-like; ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins

    2. NM_001373039.2 → NP_001360568.1  Aldehyde dehydrogenase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WWU7
      Conserved Domains (1) summary
      cd07087
      Location:5 → 430
      ALDH_F3-13-14_CALDH-like; ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins

    3. NM_171472.6 → NP_741554.1  Aldehyde dehydrogenase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741554.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MXJ7
      Conserved Domains (1) summary
      cd07087
      Location:5 → 430
      ALDH_F3-13-14_CALDH-like; ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins

    4. NM_171471.9 → NP_741553.1  Aldehyde dehydrogenase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741553.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O16518
      Conserved Domains (1) summary
      cd07087
      Location:5 → 430
      ALDH_F3-13-14_CALDH-like; ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins
    Nucleotide Protein
    Heading Accession and Version

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