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    ape-1 Apoptotic enhancer 1 protein [ Caenorhabditis elegans ]

    Gene ID: 179601, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ape-1
    Official Full Name
    Apoptotic enhancer 1 protein
    Primary source
    WormBase:WBGene00000146
    Locus tag
    CELE_F46F3.4
    See related
    AllianceGenome:WB:WBGene00000146
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables p53 binding activity. Involved in negative regulation of apoptotic process. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including pharyngeal-intestinal valve; somatic nervous system; and spermatheca. Orthologous to several human genes including PPP1R13B (protein phosphatase 1 regulatory subunit 13B) and TP53BP2 (tumor protein p53 binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ape-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (11675938..11685274)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Continuous and discontinuous multi-generational disturbances of tetrabromobisphenol A on longevity in Caenorhabditis elegans. Liu F, et al. Ecotoxicol Environ Saf, 2023 Feb. PMID 36628875
    2. The Caenorhabditis elegans ASPP homolog APE-1 is a junctional protein phosphatase 1 modulator. Beacham GM, et al. Genetics, 2022 Aug 30. PMID 35792852, Free PMC Article
    3. iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human. Bergamaschi D, et al. Nat Genet, 2003 Feb. PMID 12524540
    4. Assessment of stress-related gene expression in the heavy metal-exposed nematode Caenorhabditis elegans: a potential biomarker for metal-induced toxicity monitoring and environmental risk assessment. Roh JY, et al. Environ Toxicol Chem, 2006 Nov. PMID 17089718
    5. Evaluating the adverse effects and mechanisms of nanomaterial exposure on longevity of C. elegans: A literature meta-analysis and bioinformatics analysis of multi-transcriptome data. Yin F, et al. Environ Res, 2024 Apr 15. PMID 38224941

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables p53 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables p53 binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables p53 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Apoptotic enhancer 1 protein
    NP_001256353.1
    • Confirmed by transcript evidence
    NP_001256354.1
    • Confirmed by transcript evidence
    NP_001256355.1
    • Confirmed by transcript evidence
    NP_001256356.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11675938..11685274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269424.2 → NP_001256353.1  Apoptotic enhancer 1 protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256353.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E0AHC9, E0AHD0, E0AHD1, Q9XVN3
      Conserved Domains (5) summary
      smart00326
      Location:687 → 742
      SH3; Src homology 3 domains
      cd00204
      Location:578 → 674
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam10231
      Location:154 → 225
      DUF2315; uncharacterized conserved protein (DUF2315)
      pfam13637
      Location:588 → 639
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:585 → 616
      ANK; ANK repeat [structural motif]

    2. NM_001269425.4 → NP_001256354.1  Apoptotic enhancer 1 protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256354.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E0AHC9
      Conserved Domains (5) summary
      smart00326
      Location:623 → 678
      SH3; Src homology 3 domains
      cd00204
      Location:514 → 610
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam10231
      Location:90 → 161
      DUF2315; uncharacterized conserved protein (DUF2315)
      pfam13637
      Location:524 → 575
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:521 → 552
      ANK; ANK repeat [structural motif]

    3. NM_001269426.3 → NP_001256355.1  Apoptotic enhancer 1 protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256355.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E0AHD0
      Conserved Domains (4) summary
      smart00326
      Location:351 → 406
      SH3; Src homology 3 domains
      cd00204
      Location:242 → 338
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam13637
      Location:252 → 303
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:249 → 280
      ANK; ANK repeat [structural motif]

    4. NM_001269427.3 → NP_001256356.1  Apoptotic enhancer 1 protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256356.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E0AHD1
      Conserved Domains (4) summary
      smart00326
      Location:259 → 314
      SH3; Src homology 3 domains
      cd00204
      Location:150 → 246
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam13637
      Location:160 → 211
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:157 → 188
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XVN3.1

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