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    gba-1 Putative glucosylceramidase 1 [ Caenorhabditis elegans ]

    Gene ID: 173574, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gba-1
    Official Full Name
    Putative glucosylceramidase 1
    Primary source
    WormBase:WBGene00016335
    Locus tag
    CELE_C33C12.3
    See related
    AllianceGenome:WB:WBGene00016335
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glucosylceramidase activity. Predicted to be involved in glucosylceramide catabolic process. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gba-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    13
    Sequence:
    Chromosome: II; NC_003280.10 (2176741..2182510)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene AMP-binding_C domain-containing protein Neighboring gene Putative glucosylceramidase 2 Neighboring gene Methyltransferase small domain-containing protein Neighboring gene Membralin;TMV resistance protein N-like Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reverse genetic screening during L1 arrest reveals a role of the diacylglycerol kinase 1 gene dgk-1 and sphingolipid metabolism genes in sleep regulation. Koutsoumparis A, et al. Genetics, 2023 Oct 4. PMID 37682641
    2. Analysis of Caenorhabditis elegans phosphoproteome reveals the involvement of a molecular chaperone, HSP-90 protein during Salmonella enterica Serovar Typhi infection. Balasubramaniam B, et al. Int J Biol Macromol, 2019 Sep 15. PMID 31252012
    3. Degradation of hexosylceramides is required for timely corpse clearance via formation of cargo-containing phagolysosomal vesicles. Holzapfel R, et al. Eur J Cell Biol, 2024 Jun. PMID 38582051
    4. Improved Biocompatibility of Amino-Functionalized Graphene Oxide in Caenorhabditis elegans. Rive C, et al. Small, 2019 Nov. PMID 31576668
    5. Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans. Sun Y, et al. Elife, 2020 Jun 2. PMID 32482227, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables glucosylceramidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucosylceramidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glucosylceramide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Putative glucosylceramidase 1
    NP_001040750.1
    • Confirmed by transcript evidence
    NP_001040751.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      2176741..2182510
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047285.3 → NP_001040750.1  Putative glucosylceramidase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040750.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8DZ32, O16580
      Conserved Domains (1) summary
      pfam02055
      Location:23 → 519
      Glyco_hydro_30; O-Glycosyl hydrolase family 30

    2. NM_001047286.3 → NP_001040751.1  Putative glucosylceramidase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040751.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16580
      Conserved Domains (1) summary
      cl23815
      Location:1 → 466
      Glyco_hydro_30; O-Glycosyl hydrolase family 30
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O16580.2

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