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    npp-21 TPR_MLP1_2 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174232, updated on 9-Dec-2024

    Summary

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    Official Symbol
    npp-21
    Official Full Name
    TPR_MLP1_2 domain-containing protein
    Primary source
    WormBase:WBGene00019940
    Locus tag
    CELE_R07G3.3
    See related
    AllianceGenome:WB:WBGene00019940
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be a structural constituent of nuclear pore. Predicted to be involved in mRNA export from nucleus and regulation of mitotic spindle assembly. Predicted to be located in nuclear envelope. Predicted to be part of nuclear pore. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder. Orthologous to human TPR (translocated promoter region, nuclear basket protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See npp-21 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    21
    Sequence:
    Chromosome: II; NC_003280.10 (7599657..7608016)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Serine/threonine-protein phosphatase Pgam5, mitochondrial Neighboring gene Osmotic avoidance abnormal protein 8 Neighboring gene LIPaSe related Neighboring gene Uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Autophagy genes are essential for dauer development and life-span extension in C. elegans. Meléndez A, et al. Science, 2003 Sep 5. PMID 12958363
    2. Analysis of Nuclear Pore Complexes in Caenorhabditis elegans by Live Imaging and Functional Genomics. de la Cruz Ruiz P, et al. Methods Mol Biol, 2022. PMID 35412238
    3. In-vivo screening implicates endoribonuclease Regnase-1 in modulating senescence-associated lysosomal changes. Venz R, et al. Geroscience, 2024 Apr. PMID 37644339, Free PMC Article
    4. Nucleoporin foci are stress-sensitive condensates dispensable for C. elegans nuclear pore assembly. Thomas L, et al. EMBO J, 2023 Jul 3. PMID 37254647, Free PMC Article
    5. PP2A-B55(SUR-6) promotes nuclear envelope breakdown in C. elegans embryos. Kapoor S, et al. Cell Rep, 2023 Dec 26. PMID 37995185

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TPR_MLP1_2 domain-containing protein
    NP_001360023.1
    • Confirmed by transcript evidence
    NP_001360024.1
    • Confirmed by transcript evidence
    NP_001360471.1
    • Confirmed by transcript evidence
    NP_001360472.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7599657..7608016
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373744.2 → NP_001360023.1  TPR_MLP1_2 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5WRT8
      Conserved Domains (3) summary
      PTZ00449
      Location:1424 → 1746
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      COG1196
      Location:25 → 814
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam03154
      Location:1446 → 1586
      Atrophin-1; Atrophin-1 family

    2. NM_001373743.2 → NP_001360024.1  TPR_MLP1_2 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5WRT9
      Conserved Domains (3) summary
      PTZ00449
      Location:1424 → 1746
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      COG1196
      Location:25 → 814
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam03154
      Location:1446 → 1586
      Atrophin-1; Atrophin-1 family

    3. NM_001373741.2 → NP_001360471.1  TPR_MLP1_2 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WX27
      Conserved Domains (3) summary
      COG1196
      Location:25 → 814
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PTZ00108
      Location:1225 → 1500
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam05109
      Location:1467 → 1642
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

    4. NM_001373742.2 → NP_001360472.1  TPR_MLP1_2 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WY01
      Conserved Domains (3) summary
      PTZ00449
      Location:1424 → 1748
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      COG1196
      Location:25 → 814
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam03154
      Location:1446 → 1586
      Atrophin-1; Atrophin-1 family

    RNA

    1. NR_151568.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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