U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ctsa-4.1 Serine carboxypeptidase ctsa-4.1 [ Caenorhabditis elegans ]

    Gene ID: 174057, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ctsa-4.1
    Official Full Name
    Serine carboxypeptidase ctsa-4.1
    Primary source
    WormBase:WBGene00019605
    Locus tag
    CELE_K10B2.2
    See related
    AllianceGenome:WB:WBGene00019605
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable serine-type carboxypeptidase activity. Predicted to be involved in proteolysis. Human ortholog(s) of this gene implicated in galactosialidosis and lysosomal storage disease. Orthologous to human CTSA (cathepsin A). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ctsa-4.1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003280.10 (6366996..6369091)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Protein Asterix Neighboring gene Anillin-like protein 2 Neighboring gene C-type lectin domain-containing protein;C-type lectin domain-containing protein 88 Neighboring gene ncRNA Neighboring gene F-box domain-containing protein;F-box/WD repeat-containing protein lin-23

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identifying evolutionarily conserved genes in the dietary restriction response using bioinformatics and subsequent testing in Caenorhabditis elegans. Ludewig AH, et al. Genes Nutr, 2014 Jan. PMID 24311442, Free PMC Article
    2. Sexual dimorphism in Caenorhabditis elegans stress resistance. Piloto JH, et al. PLoS One, 2022. PMID 35951614, Free PMC Article
    3. The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress. Li TY, et al. Nat Aging, 2021 Feb. PMID 33718883, Free PMC Article
    4. Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans. Sun Y, et al. Elife, 2020 Jun 2. PMID 32482227, Free PMC Article
    5. Increasing Complexity of the N-Glycome During Caenorhabditis Development. Wilson IBH, et al. Mol Cell Proteomics, 2023 Mar. PMID 36717059, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type carboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Serine carboxypeptidase ctsa-4.1
    NP_001379755.1
    • Confirmed by transcript evidence
    NP_495284.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      6366996..6369091
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062883.8 → NP_495284.1  Serine carboxypeptidase ctsa-4.1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495284.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09991, Q86NG2
      Conserved Domains (1) summary
      pfam00450
      Location:30 → 460
      Peptidase_S10; Serine carboxypeptidase

    2. NM_001393099.1 → NP_001379755.1  Serine carboxypeptidase ctsa-4.1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cl08270
      Location:1 → 194
      Peptidase_S10; Serine carboxypeptidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09991.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous