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    mak-1 MAP kinase-activated protein kinase mak-1 [ Caenorhabditis elegans ]

    Gene ID: 174398, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mak-1
    Official Full Name
    MAP kinase-activated protein kinase mak-1
    Primary source
    WormBase:WBGene00010681
    Locus tag
    CELE_K08F8.1
    See related
    AllianceGenome:WB:WBGene00010681
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein kinase activity and protein kinase binding activity. Involved in adult locomotory behavior; behavioral response to nicotine; and protein autophosphorylation. Located in A band. Is expressed in several structures, including body wall musculature; excretory cell; intestine; pharynx; and tail. Human ortholog(s) of this gene implicated in patterned macular dystrophy 3. Orthologous to human MAPKAPK2 (MAPK activated protein kinase 2) and MAPKAPK3 (MAPK activated protein kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mak-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    8
    Sequence:
    Chromosome: II; NC_003280.10 (8744071..8747250)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Cuticle collagen rol-6 Neighboring gene Intrinsically Disordered Protein, class B Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Twitchin kinase interacts with MAPKAP kinase 2 in Caenorhabditis elegans striated muscle. Matsunaga Y, et al. Mol Biol Cell, 2015 Jun 1. PMID 25851606, Free PMC Article
    2. A genome-wide map of conserved microRNA targets in C. elegans. Lall S, et al. Curr Biol, 2006 Mar 7. PMID 16458514
    3. The mechanoreceptor DEG-1 regulates cold tolerance in Caenorhabditis elegans. Takagaki N, et al. EMBO Rep, 2020 Mar 4. PMID 32009302, Free PMC Article
    4. A novel biochemical method to identify target genes of individual microRNAs: identification of a new Caenorhabditis elegans let-7 target. Andachi Y. RNA, 2008 Nov. PMID 18824511, Free PMC Article
    5. Gamma radiation induces life stage-dependent reprotoxicity in Caenorhabditis elegans via impairment of spermatogenesis. Maremonti E, et al. Sci Total Environ, 2019 Dec 10. PMID 31425988

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MAK-1 is an activator of twitchin kinase and that the p38 MAP kinase pathway may be involved in the regulation of twitchin.
      Title: Twitchin kinase interacts with MAPKAP kinase 2 in Caenorhabditis elegans striated muscle.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium/calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mitogen-activated protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in behavioral response to nicotine IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in behavioral response to nicotine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein autophosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in regulation of sarcomere organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in A band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in A band IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sarcomere IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    MAP kinase-activated protein kinase mak-1
    NP_001022238.1
    • Confirmed by transcript evidence
    NP_001359655.1
    • Confirmed by transcript evidence
    NP_001359681.1
    • Confirmed by transcript evidence
    NP_001367107.1
    • Partially confirmed by transcript evidence
    NP_495860.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8744071..8747250
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373775.3 → NP_001359655.1  MAP kinase-activated protein kinase mak-1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cl21453
      Location:142 → 335
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001373776.3 → NP_001359681.1  MAP kinase-activated protein kinase mak-1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cd14089
      Location:142 → 381
      STKc_MAPKAPK; Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase-activated protein kinases

    3. NM_063459.5 → NP_495860.1  MAP kinase-activated protein kinase mak-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495860.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21360, Q65ZB6, Q65ZB7, Q7JM88, Q8I117
      Conserved Domains (1) summary
      cd14089
      Location:142 → 403
      STKc_MAPKAPK; Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase-activated protein kinases

    4. NM_001027067.5 → NP_001022238.1  MAP kinase-activated protein kinase mak-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022238.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21360
      Conserved Domains (2) summary
      smart00220
      Location:3 → 247
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14089
      Location:1 → 245
      STKc_MAPKAPK; Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase-activated protein kinases

    5. NM_001381538.1 → NP_001367107.1  MAP kinase-activated protein kinase mak-1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cl21453
      Location:1 → 223
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21360.1

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