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    nst-1 Guanine nucleotide-binding protein-like 3 homolog [ Caenorhabditis elegans ]

    Gene ID: 174329, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nst-1
    Official Full Name
    Guanine nucleotide-binding protein-like 3 homolog
    Primary source
    WormBase:WBGene00003821
    Locus tag
    CELE_K01C8.9
    See related
    AllianceGenome:WB:WBGene00003821
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTP binding activity. Involved in germ cell development; nematode larval development; and regulation of growth. Located in nucleolus and nucleoplasm. Is expressed widely. Used to study obesity. Orthologous to several human genes including GNL3L (G protein nucleolar 3 like). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nst-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (8281162..8283208, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Mitochondrial folate transporter/carrier Neighboring gene Large ribosomal subunit protein uL10m Neighboring gene C-type lectin domain-containing protein Neighboring gene T-complex protein 1 subunit delta Neighboring gene Neuropeptide-Like Protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans nucleostemin is required for larval growth and germline stem cell division. Kudron MM, et al. PLoS Genet, 2008 Aug 22. PMID 18725931, Free PMC Article
    2. Alterations in ribosome biogenesis cause specific defects in C. elegans hermaphrodite gonadogenesis. Voutev R, et al. Dev Biol, 2006 Oct 1. PMID 16876152
    3. ced-4 and proto-oncogene tfg-1 antagonistically regulate cell size and apoptosis in C. elegans. Chen L, et al. Curr Biol, 2008 Jul 22. PMID 18635357, Free PMC Article
    4. Genes in human obesity loci are causal obesity genes in C. elegans. Ke W, et al. PLoS Genet, 2021 Sep. PMID 34492009, Free PMC Article
    5. Gamma radiation induces life stage-dependent reprotoxicity in Caenorhabditis elegans via impairment of spermatogenesis. Maremonti E, et al. Sci Total Environ, 2019 Dec 10. PMID 31425988

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nucleostemin plays roles in cell growth and proliferation by promoting ribosome biogenesis.
      Title: C. elegans nucleostemin is required for larval growth and germline stem cell division.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Guanine nucleotide-binding protein-like 3 homolog
    NP_495749.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8281162..8283208 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063348.7 → NP_495749.1  Guanine nucleotide-binding protein-like 3 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495749.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21086
      Conserved Domains (4) summary
      cd04178
      Location:149 → 314
      Nucleostemin_like; A circularly permuted subfamily of the Ras GTPases
      COG1161
      Location:140 → 439
      RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]
      pfam08701
      Location:17 → 84
      GN3L_Grn1; GNL3L/Grn1 putative GTPase
      cl21455
      Location:263 → 401
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21086.1

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