atl-1 Serine/threonine-protein kinase ATR [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: atl-1
Official Full Name: Serine/threonine-protein kinase ATR
Primary source: WormBase:WBGene00000226
Locus tag: CELE_T06E4.3
See related: AllianceGenome:WB:WBGene00000226
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable 1-phosphatidylinositol-3-kinase activity and protein serine/threonine kinase activity. Involved in DNA damage checkpoint signaling; embryo development; and meiotic chromosome segregation. Located in nucleus. Is expressed in gonad. Human ortholog(s) of this gene implicated in Seckel syndrome 1; adenoid cystic carcinoma; colon cancer; lung cancer; and pancreatic cancer. Orthologous to human ATR (ATR serine/threonine kinase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See atl-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 18

Sequence:: Chromosome: V; NC_003283.11 (9634861..9645474, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The data suggest a model in which ATM-1 and ATL-1 have antagonistic roles in very early repair processing, but are redundantly required for accumulation of the RAD-51 recombinase at DSB sites.
Title: ATM and ATR Influence Meiotic Crossover Formation Through Antagonistic and Overlapping Functions in Caenorhabditis elegans.
ATL-1 functions to maintain mtDNA independently of ribonucleotide reductase
Title: Maintenance of mitochondrial DNA by the Caenorhabditis elegans ATR checkpoint protein ATL-1.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T06E4.3 (e-PCR)
- UniSTS:307951

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA damage checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in telomere maintenance	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in chromosome	IBA Inferred from Biological aspect of Ancestor more info
located_in condensed nuclear chromosome	TAS Traceable Author Statement more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Serine/threonine-protein kinase ATR

NP_001256128.1

Confirmed by transcript evidence

NP_505487.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

9634861..9645474 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_073086.6 → NP_505487.3 Serine/threonine-protein kinase ATR [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_505487.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q22258, Q9Y061

Conserved Domains (3) summary

cd05164
Location:2189 → 2458

PIKKc; Catalytic domain of Phosphoinositide 3-kinase-related protein kinases

pfam02259
Location:1627 → 1873

FAT; FAT domain

pfam02260
Location:2500 → 2529

FATC; FATC domain
NM_001269199.3 → NP_001256128.1 Serine/threonine-protein kinase ATR [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256128.1

Status: REVIEWED

UniProtKB/TrEMBL

E5QCG9

Conserved Domains (3) summary

cd05164
Location:715 → 984

PIKKc; Catalytic domain of Phosphoinositide 3-kinase-related protein kinases

pfam02259
Location:153 → 399

FAT; FAT domain

pfam02260
Location:1026 → 1055

FATC; FATC domain