pelo-1 Protein pelota homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pelo-1
Official Full Name: Protein pelota homolog
Primary source: WormBase:WBGene00011280
Locus tag: CELE_R74.6
See related: AllianceGenome:WB:WBGene00011280
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable metal ion binding activity. Predicted to be involved in nonfunctional rRNA decay; nuclear-transcribed mRNA catabolic process, no-go decay; and ribosome disassembly. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in body wall musculature and nervous system. Orthologous to human PELO (pelota mRNA surveillance and ribosome rescue factor). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pelo-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 8

Sequence:: Chromosome: III; NC_003281.10 (4202253..4204222, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R74.7 (e-PCR)
- UniSTS:310582

R74.6 (e-PCR)
- UniSTS:307885

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA surveillance	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in nonfunctional rRNA decay	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear-transcribed mRNA catabolic process, no-go decay	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear-transcribed mRNA catabolic process, no-go decay	IEA Inferred from Electronic Annotation more info
involved_in nuclear-transcribed mRNA catabolic process, non-stop decay	IEA Inferred from Electronic Annotation more info
involved_in ribosome disassembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Protein pelota homolog

NP_497842.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

4202253..4204222 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065441.6 → NP_497842.1 Protein pelota homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497842.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P50444

Conserved Domains (4) summary

COG1537
Location:14 → 371

PelA; Stalled ribosome rescue protein Dom34, pelota family [Translation, ribosomal structure and biogenesis]

pfam03463
Location:1 → 128

eRF1_1; eRF1 domain 1

pfam03464
Location:142 → 268

eRF1_2; eRF1 domain 2

pfam03465
Location:273 → 370

eRF1_3; eRF1 domain 3