mex-3 Growth-regulating factor;K Homology domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mex-3
Official Full Name: Growth-regulating factor;K Homology domain-containing protein
Primary source: WormBase:WBGene00003229
Locus tag: CELE_F53G12.5
See related: AllianceGenome:WB:WBGene00003229
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables single-stranded RNA binding activity. Involved in several processes, including negative regulation of muscle cell differentiation; organelle inheritance; and regulation of gene expression. Located in P granule. Is expressed in distal tip cell; embryonic cell; germ line; and oocyte. Orthologous to several human genes including MEX3A (mex-3 RNA binding family member A) and MEX3B (mex-3 RNA binding family member B). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mex-3 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 8

Sequence:: Chromosome: I; NC_003279.8 (127285..134270)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The endogenous mex-3 3 UTR is required for germline repression and contributes to optimal fecundity in C. elegans.
Title: The endogenous mex-3 3´UTR is required for germline repression and contributes to optimal fecundity in C. elegans.
Results indicate that mex-3 activity is regulated at multiple levels, leading to rapid and robust regulation in the quickly developing early embryo.
Title: The RNA binding protein MEX-3 retains asymmetric activity in the early Caenorhabditis elegans embryo in the absence of asymmetric protein localization.
Results suggest that PUF-8 and MEX-3 contribute to germline stem cell maintenance by promoting mitotic proliferation rather than by blocking meiotic entry.
Title: C. elegans RNA-binding proteins PUF-8 and MEX-3 function redundantly to promote germline stem cell mitosis.
findings show that two conserved translational regulators, MEX-3 and GLD-1, are essential for maintaining totipotency in the Caenorhabditis elegans germline
Title: Translational regulators maintain totipotency in the Caenorhabditis elegans germline.
Degradation of this maternally supplied cell fate determinant is delayed in oma-1(zu405) mutant embryos.
Title: A gain-of-function mutation in oma-1, a C. elegans gene required for oocyte maturation, results in delayed degradation of maternal proteins and embryonic lethality.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F53G12.5 (e-PCR)
- UniSTS:319396

STS1-1 (e-PCR)
- UniSTS:241582

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables single-stranded RNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of muscle cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in organelle inheritance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in P granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Growth-regulating factor;K Homology domain-containing protein

NP_001293263.1

Confirmed by transcript evidence

NP_001367884.1

Confirmed by transcript evidence

NP_490681.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

127285..134270

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058280.9 → NP_490681.2 K Homology domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_490681.2

Status: REVIEWED

UniProtKB/TrEMBL

H2L067, Q94140

Conserved Domains (2) summary

smart00322
Location:164 → 229

KH; K homology RNA-binding domain

cd00105
Location:79 → 139

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
NM_001381229.2 → NP_001367884.1 K Homology domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q94140, Q95R07

Conserved Domains (1) summary

cl00098
Location:134 → 205

KH-I; K homology (KH) RNA-binding domain, type I
NM_001306334.3 → NP_001293263.1 Growth-regulating factor [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293263.1

Status: REVIEWED

UniProtKB/TrEMBL

V6CKQ3