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    efa-6 Exchange factor for Arf-6 [ Caenorhabditis elegans ]

    Gene ID: 178217, updated on 9-Dec-2024

    Summary

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    Official Symbol
    efa-6
    Official Full Name
    Exchange factor for Arf-6
    Primary source
    WormBase:WBGene00013223
    Locus tag
    CELE_Y55D9A.1
    See related
    AllianceGenome:WB:WBGene00013223
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Involved in several processes, including mitotic nuclear membrane disassembly; negative regulation of axon extension involved in regeneration; and regulation of cell cycle process. Located in cell cortex; microtubule minus-end; and plasma membrane. Is expressed in U.la; U.lp; and linker cell. Orthologous to several human genes including PSD (pleckstrin and Sec7 domain containing). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See efa-6 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    10
    Sequence:
    Chromosome: IV; NC_003282.8 (12605695..12614724, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Multidrug resistance protein pgp-1 Neighboring gene ncRNA Neighboring gene tRNA-Lys Neighboring gene G-patch domain-containing protein Neighboring gene Ack-related non-receptor tyrosine kinase Neighboring gene Transcriptional regulator

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The microtubule regulator EFA-6 forms cortical foci dependent on its intrinsically disordered region and interactions with tubulins. Sandhu A, et al. Cell Rep, 2024 Oct 22. PMID 39305484
    2. Regulation of Microtubule Dynamics in Axon Regeneration: Insights from C. elegans. Tang NH, et al. F1000Res, 2016. PMID 27350865, Free PMC Article
    3. Recent advances in the understanding and management of IgA nephropathy. Lai KN, et al. F1000Res, 2016. PMID 26918170, Free PMC Article
    4. Axon regeneration pathways identified by systematic genetic screening in C. elegans. Chen L, et al. Neuron, 2011 Sep 22. PMID 21943602, Free PMC Article
    5. DIP-2 suppresses ectopic neurite sprouting and axonal regeneration in mature neurons. Noblett N, et al. J Cell Biol, 2019 Jan 7. PMID 30396999, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The microtubule regulator EFA-6 forms cortical foci dependent on its intrinsically disordered region and interactions with tubulins.
      Title: The microtubule regulator EFA-6 forms cortical foci dependent on its intrinsically disordered region and interactions with tubulins.
    2. It loss of EFA-6, a modulator of MT dynamics, can delay both neuronal aging and extend the lifespan of C. elegans.
      Title: Microtubule regulators act in the nervous system to modulate fat metabolism and longevity through DAF-16 in C. elegans.
    3. The EFA-6 N-terminus binds the microtubule-associated proteins TAC-1/Transforming-Acidic-Coiled-Coil, and ZYG-8/Doublecortin-Like-Kinase, both of which are required for regenerative growth cone formation, and which act downstream of EFA-6.
      Title: Axon injury triggers EFA-6 mediated destabilization of axonal microtubules via TACC and doublecortin like kinase.
    4. C. elegans EFA-6 amino-terminus is both necessary and sufficient to limit microtubule growth along the cortex, and that this function is independent of ARF-6.
      Title: Caenorhabditis elegans EFA-6 limits microtubule growth at the cell cortex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic nuclear membrane disassembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of axon extension involved in regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of axon regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of mitotic spindle elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of microtubule cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of mitotic centrosome separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to axon injury IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule minus-end IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Exchange factor for Arf-6
    NP_001122818.1
    • Confirmed by transcript evidence
    NP_001255652.1
    • Confirmed by transcript evidence
    NP_502416.1
    • Confirmed by transcript evidence
    NP_502417.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      12605695..12614724 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070015.7 → NP_502416.1  Exchange factor for Arf-6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502416.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D4YWC5, G5EBY7, G5EET6, Q9XWG7
      Conserved Domains (3) summary
      smart00222
      Location:350 → 534
      Sec7; Sec7 domain
      cd13295
      Location:565 → 689
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
      pfam00169
      Location:571 → 681
      PH; PH domain

    2. NM_001129346.3 → NP_001122818.1  Exchange factor for Arf-6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122818.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EET6
      Conserved Domains (4) summary
      smart00222
      Location:297 → 481
      Sec7; Sec7 domain
      cd13295
      Location:512 → 636
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
      pfam00169
      Location:518 → 628
      PH; PH domain
      cl01319
      Location:139 → 192
      HARE-HTH; HB1, ASXL, restriction endonuclease HTH domain

    3. NM_070016.7 → NP_502417.1  Exchange factor for Arf-6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502417.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EET6
      Conserved Domains (3) summary
      smart00222
      Location:348 → 532
      Sec7; Sec7 domain
      cd13295
      Location:563 → 687
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
      pfam00169
      Location:569 → 679
      PH; PH domain

    4. NM_001268723.3 → NP_001255652.1  Exchange factor for Arf-6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255652.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EET6
      Conserved Domains (3) summary
      smart00222
      Location:166 → 350
      Sec7; Sec7 domain
      cd13295
      Location:381 → 505
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
      pfam00169
      Location:387 → 497
      PH; PH domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EET6.1

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