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    scav-2 SCAVenger receptor (CD36 family) related [ Caenorhabditis elegans ]

    Gene ID: 176787, updated on 9-Dec-2024

    Summary

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    Official Symbol
    scav-2
    Official Full Name
    SCAVenger receptor (CD36 family) related
    Primary source
    WormBase:WBGene00013578
    Locus tag
    CELE_Y76A2B.6
    See related
    AllianceGenome:WB:WBGene00013578
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable scavenger receptor activity. Predicted to be involved in vesicle-mediated transport. Predicted to be active in membrane. Is expressed in reproductive system. Human ortholog(s) of this gene implicated in several diseases, including blood platelet disease (multiple); hemolytic-uremic syndrome; osteoarthritis; progressive myoclonus epilepsy 4; and pulmonary tuberculosis. Orthologous to several human genes including SCARB1 (scavenger receptor class B member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See scav-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (13550601..13555334, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Methylmalonic aciduria and homocystinuria type D homolog, mitochondrial Neighboring gene F-box associated domain-containing protein Neighboring gene Fructose-bisphosphate aldolase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36. Means TK, et al. J Exp Med, 2009 Mar 16. PMID 19237602, Free PMC Article
    2. SCAV-3 affects apoptotic cell degradation in Caenorhabditis elegans. Ma A, et al. FEBS Open Bio, 2023 May. PMID 36947094, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables scavenger receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SCAVenger receptor (CD36 family) related
    NP_499802.3
    • Confirmed by transcript evidence;
      Product from WormBase gene class scav

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      13550601..13555334 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067401.7 → NP_499802.3  SCAVenger receptor (CD36 family) related [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499802.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBM7
      Conserved Domains (1) summary
      pfam01130
      Location:46 → 505
      CD36; CD36 family
    Nucleotide Protein
    Heading Accession and Version

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