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    ikb-1 Death domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172817, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ikb-1
    Official Full Name
    Death domain-containing protein
    Primary source
    WormBase:WBGene00002069
    Locus tag
    CELE_C04F12.3
    See related
    AllianceGenome:WB:WBGene00002069
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable NF-kappaB binding activity. Involved in defense response to Gram-negative bacterium. Located in cytoplasm. Human ortholog(s) of this gene implicated in common variable immunodeficiency 10. Orthologous to human NFKB2 (nuclear factor kappa B subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ikb-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (9685398..9688653)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Piwi domain-containing protein Neighboring gene tRNA Neighboring gene Large ribosomal subunit protein eL14 Neighboring gene Activin_recp domain-containing protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development. Brena D, et al. Sci Rep, 2020 Sep 30. PMID 32999373, Free PMC Article
    2. Large-scale genetic screens identify BET-1 as a cytoskeleton regulator promoting actin function and life span. Garcia G, et al. Aging Cell, 2023 Jan. PMID 36404134, Free PMC Article
    3. A conserved Toll-like receptor is required for Caenorhabditis elegans innate immunity. Tenor JL, et al. EMBO Rep, 2008 Jan. PMID 17975555, Free PMC Article
    4. A reverse genetic analysis of components of the Toll signaling pathway in Caenorhabditis elegans. Pujol N, et al. Curr Biol, 2001 Jun 5. PMID 11516642
    5. Dissecting worm immunity. Hodgkin J. Nat Immunol, 2004 May. PMID 15116111

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 

    General protein information

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    Preferred Names
    Death domain-containing protein
    NP_492575.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9685398..9688653
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060174.6 → NP_492575.1  Death domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492575.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFS1
      Conserved Domains (4) summary
      cd08310
      Location:515 → 592
      Death_NFkB-like; Death domain of Nuclear Factor-KappaB precursor proteins
      sd00045
      Location:282 → 313
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:153 → 243
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:206 → 399
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein
    Heading Accession and Version

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