hsp-16.41 Heat shock protein Hsp-16.41 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hsp-16.41
Official Full Name: Heat shock protein Hsp-16.41
Primary source: WormBase:WBGene00002018
Locus tag: CELE_Y46H3A.2
See related: AllianceGenome:WB:WBGene00002018
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable unfolded protein binding activity. Involved in defense response to Gram-negative bacterium and response to heat. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary muscle; coelomocyte; intestine; neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in cataract 9 multiple types. Orthologous to human CRYAA (crystallin alpha A). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hsp-16.41 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 2

Sequence:: Chromosome: V; NC_003283.11 (1805178..1805875)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y46H3A.d (e-PCR)
- UniSTS:322905

Y46H3A.e (e-PCR)
- UniSTS:322906

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in IRE1-mediated unfolded protein response	HEP more info	PubMed
involved_in defense response to Gram-negative bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in endoplasmic reticulum unfolded protein response	HEP more info	PubMed
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to heat	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to heat	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Heat shock protein Hsp-16.41

NP_872116.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

1805178..1805875

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_182316.5 → NP_872116.2 Heat shock protein Hsp-16.41 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_872116.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P02514, P06581

Conserved Domains (1) summary

cd06526
Location:46 → 127

metazoan_ACD; Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are ...