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    skr-4 Skp1-related protein [ Caenorhabditis elegans ]

    Gene ID: 191762, updated on 9-Dec-2024

    Summary

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    Official Symbol
    skr-4
    Official Full Name
    Skp1-related protein
    Primary source
    WormBase:WBGene00004810
    Locus tag
    CELE_Y60A3A.18
    See related
    AllianceGenome:WB:WBGene00004810
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cullin family protein binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm and nucleus. Is expressed in intestine. Orthologous to human SKP1 (S-phase kinase associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See skr-4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (19924224..19925033)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene non-specific serine/threonine protein kinase Neighboring gene pseudo Neighboring gene pseudo Neighboring gene UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A cullin-RING ubiquitin ligase promotes thermotolerance as part of the intracellular pathogen response in Caenorhabditis elegans. Panek J, et al. Proc Natl Acad Sci U S A, 2020 Apr 7. PMID 32193347, Free PMC Article
    2. Multiple pals gene modules control a balance between immunity and development in Caenorhabditis elegans. Lažetić V, et al. PLoS Pathog, 2023 Jul. PMID 37463170, Free PMC Article
    3. Multiple Skp1-related proteins in Caenorhabditis elegans: diverse patterns of interaction with Cullins and F-box proteins. Yamanaka A, et al. Curr Biol, 2002 Feb 19. PMID 11864566
    4. The purine nucleoside phosphorylase pnp-1 regulates epithelial cell resistance to infection in C. elegans. Tecle E, et al. PLoS Pathog, 2021 Apr. PMID 33878133, Free PMC Article
    5. The transcription factor ZIP-1 promotes resistance to intracellular infection in Caenorhabditis elegans. Lažetić V, et al. Nat Commun, 2022 Jan 10. PMID 35013162, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Skp1-related protein
    NP_507857.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      19924224..19925033
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075456.7 → NP_507857.1  Skp1-related protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507857.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U1Y9
      Conserved Domains (3) summary
      smart00512
      Location:7 → 110
      Skp1; Found in Skp1 protein family
      COG5201
      Location:10 → 159
      SKP1; SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, chaperones]
      pfam01466
      Location:84 → 157
      Skp1; Skp1 family, dimerization domain
    Nucleotide Protein
    Heading Accession and Version

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